Article Figures & Data
Figures
- Figure 1.
Gross image of appendiceal neuroendocrine tumor. (A) The gross image from patient 6 shows a well-circumscribed, 3 cm mass with encapsulation in the small intestine mesentery on the left side of the image. On the right side of the image, a lesion filling the lumen of the appendix can be observed. (B) A longitudinal-section of the appendix also reveals a lumen filled with an irregularly bordered lesion. However, no gross invasion of the periappendiceal adipose tissue by the mass is observed.
- Figure 2.
Representative histopathological features on hematoxylin and eosin slides of appendiceal neuroendocrine tumors. (A) In patient 2, tumor cells are scattered in irregular nested, trabecular, and acinar patterns, extending from mucosa to subserosal soft tissue (×40). (B) Upon zooming in, tumor cells are identified in the subserosal layer, characterized by round or oval nuclei, finely stippled chromatin, and granular cytoplasm (×100). (C) In patient 4, the tumor cells show trabecular and nested architectural patterns, extending from mucosa to the muscularis propria layer of the appendix (×40). (D) Tumor cells are relatively few in number and widely scattered, characterized by round or oval nuclei, finely stippled chromatin, and granular cytoplasm (×100). (E) In patient 6, the tumor lesion covers the whole appendix (×12.5). (F) At low-resolution, tumor cells are observed to diffusely infiltrate the subserosal layer in nested and trabecular patterns, surrounding blood vessels (×100).
- Figure 3.
Representative immunohistochemical (IHC) results of appendiceal neuroendocrine tumors. The tumor cells are diffusely positive for CD56 (×200) (A, patient 4) and synaptophysin (B, patient 5). However, two cases are negative for chromogranin A (C, patient 4). In all tumors, Ki-67 staining is minimal in the nuclei of tumor cells, with a very low Ki-67 labeling index (less than 1%) (D, patient 5).
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