Non-Invasive Direct Visualization of Luciferase-Luciferin Emitted Light Producing True Images from an Orthotopic Lung Cancer Xenograft Model in Nude Mice Using an Ultra-sensitive Low-light Camera and Optics

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Figure 1.
Direct true image of luciferase-luciferin-emitted light from a Lewis-lung carcinoma (LL/2-Luc2) implanted orthotopically in a nude mouse captured at 15 min after injection of luciferin. Exposure time was 30 s. (Arrow; luciferase-luciferin-emitted light true image).
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Figure 2.
Time-course of direct true luciferase-luciferin images captured from a Lewis-lung carcinoma (LL/2-Luc2) orthotopic nude-mouse model. Images were captured at 5 min intervals over 30 min going from left to right and top to bottom. (Arrows; luciferase-luciferin-emitted light true image). Exposure time was 30 s.
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Figure 3.
Time-course of the intensity of the emitted light from luciferase-luciferin in the Lewis-lung carcinoma (LL/2-Luc2) in the orthotopic mouse models shown in Figure 2.
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Figure 4.
Location of the orthotopic Lewis-lung tumor (LL/2-Luc2) on the surface of the middle lobe of the right lung of a nude mouse. (Arrow; tumor in the lung).