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Proton Pump Inhibitor Associated Multiple Gastric Hyperplastic Polyps With Uncontrollable Bleeding: A Case Report

MASATOSHI NAKASHIMA, HIDEAKI NAOE, YOSHIHIRO KOMOHARA, KOTARO WAKI, HIDEAKI MIYAMOTO, YOSHINARI SAKAI, TOSHIKI KOJIMA, TAKAO KANEMITSU, KENSHI YAO and YASUHITO TANAKA
In Vivo May 2024, 38 (3) 1465-1469; DOI: https://doi.org/10.21873/invivo.13592

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  • Figure 1.
    Figure 1.

    Endoscopic image on admission. (A, B) After six years of treatment with lansoprazole, a proton pump inhibitor. In the stomach, blood and black residue accumulated. (C, D) Approximately 30-40 reddish polyps with a diameter of 3-10 mm were observed in the gastric body to antrum area.

  • Figure 2.
    Figure 2.

    Pathological analysis of gastric polyp. Hyperplasia of foveolar epithelium was observed and increased capillaries were seen in lamina propria. Both parietal cell protrusion and oxyntic gland dilatation, which are usually seen in PPI-associated polyps, were negative. (A, B); hematoxylin and eosin staining. (C); immunohistochemistry of CD34. (D, E); immunohistochemistry of OK-524, the marker of gastrin receptors.

  • Figure 3.
    Figure 3.

    Endoscopic image six months after the cessation of proton pump inhibitor treatment. Note the near-complete disappearance of gastric hyperplastic polyps.

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Proton Pump Inhibitor Associated Multiple Gastric Hyperplastic Polyps With Uncontrollable Bleeding: A Case Report
MASATOSHI NAKASHIMA, HIDEAKI NAOE, YOSHIHIRO KOMOHARA, KOTARO WAKI, HIDEAKI MIYAMOTO, YOSHINARI SAKAI, TOSHIKI KOJIMA, TAKAO KANEMITSU, KENSHI YAO, YASUHITO TANAKA
In Vivo May 2024, 38 (3) 1465-1469; DOI: 10.21873/invivo.13592
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