Effect of Liver Dysfunction on S-1 Therapy Induced Adverse Effects: A Retrospective Cohort Study

YOSUKE ANDO; YUKI SHIBATA; TAKUMA ISHIHARA; SEIRA NISHIBE-TOYOSATO; KAORI ITO; NANAHO MIYATA-HIRAGA; KENJI KAWADA; YOSHIAKI IKEDA; TAKAHIRO HAYASHI; KAZUYOSHI IMAIZUMI; SHIGEKI YAMADA

doi:10.21873/invivo.13500

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Effect of Liver Dysfunction on S-1 Therapy Induced Adverse Effects: A Retrospective Cohort Study

YOSUKE ANDO, YUKI SHIBATA, TAKUMA ISHIHARA, SEIRA NISHIBE-TOYOSATO, KAORI ITO, NANAHO MIYATA-HIRAGA, KENJI KAWADA, YOSHIAKI IKEDA, TAKAHIRO HAYASHI, KAZUYOSHI IMAIZUMI and SHIGEKI YAMADA

In Vivo March 2024, 38 (2) 767-773; DOI: https://doi.org/10.21873/invivo.13500

YOSUKE ANDO

1Department of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Toyoake, Japan;

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For correspondence: ysk-ando{at}fujita-hu.ac.jp

YUKI SHIBATA

2College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan;

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TAKUMA ISHIHARA

3Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, Japan;

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SEIRA NISHIBE-TOYOSATO

1Department of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Toyoake, Japan;

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KAORI ITO

1Department of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Toyoake, Japan;

4Faculty of Pharmacy, Meijo University, Nagoya, Japan;

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NANAHO MIYATA-HIRAGA

2College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan;

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KENJI KAWADA

5Department of Medical Oncology, Fujita Health University School of Medicine, Toyoake, Japan;

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YOSHIAKI IKEDA

2College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan;

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TAKAHIRO HAYASHI

1Department of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Toyoake, Japan;

2College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan;

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KAZUYOSHI IMAIZUMI

6Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Japan

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SHIGEKI YAMADA

1Department of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Toyoake, Japan;

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Figure 1.
Amount of change in red blood cells (RBC).
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Figure 2.
Amount of change in platelet (PLT) count.
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Figure 3.
Amount of change in total bilirubin (T-Bil).
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Figure 4.
Predicted value of platelet (PLT) count change.
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Figure 5.
Predicted value of total bilirubin (T-Bil) change.

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Effect of Liver Dysfunction on S-1 Therapy Induced Adverse Effects: A Retrospective Cohort Study

YOSUKE ANDO, YUKI SHIBATA, TAKUMA ISHIHARA, SEIRA NISHIBE-TOYOSATO, KAORI ITO, NANAHO MIYATA-HIRAGA, KENJI KAWADA, YOSHIAKI IKEDA, TAKAHIRO HAYASHI, KAZUYOSHI IMAIZUMI, SHIGEKI YAMADA

In Vivo Mar 2024, 38 (2) 767-773; DOI: 10.21873/invivo.13500

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Effect of Liver Dysfunction on S-1 Therapy Induced Adverse Effects: A Retrospective Cohort Study

YOSUKE ANDO, YUKI SHIBATA, TAKUMA ISHIHARA, SEIRA NISHIBE-TOYOSATO, KAORI ITO, NANAHO MIYATA-HIRAGA, KENJI KAWADA, YOSHIAKI IKEDA, TAKAHIRO HAYASHI, KAZUYOSHI IMAIZUMI, SHIGEKI YAMADA

In Vivo Mar 2024, 38 (2) 767-773; DOI: 10.21873/invivo.13500

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Keywords

S-1
liver dysfunction
bilirubin
Thrombocytopenia
side effects

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