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Research ArticleExperimental Studies
Open Access

Bio-characteristics and Efficacy Analysis of Biodegradable Poly Dioxanone Dermal Filler in a Mouse Model and Humans

SHU-YI ZHOU, SO MIN KANG, YEON JU GU, XIN RUI ZHANG, DONG KEON YON, BYUNG HO SHIN, JUNG RYUL HAM, WON KU LEE, JE GEUN JEONG, HAN JIN KWON and CHAN-YEONG HEO
In Vivo May 2023, 37 (3) 1093-1102; DOI: https://doi.org/10.21873/invivo.13184
SHU-YI ZHOU
1Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;
2Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea;
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SO MIN KANG
1Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;
3Korean Skin Research Center, Seongnam, Republic of Korea;
4H&BIO Corporation/R&D Center, Seongnam, Republic of Korea;
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YEON JU GU
5UltraV Co., Ltd. Research Center, Seoul, Republic of Korea;
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XIN RUI ZHANG
1Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;
2Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea;
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DONG KEON YON
6Center for Digital Health, Medical Science Research Institute, Kyung Hee University, Seoul, Republic of Korea
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BYUNG HO SHIN
1Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;
2Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea;
3Korean Skin Research Center, Seongnam, Republic of Korea;
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JUNG RYUL HAM
5UltraV Co., Ltd. Research Center, Seoul, Republic of Korea;
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WON KU LEE
5UltraV Co., Ltd. Research Center, Seoul, Republic of Korea;
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JE GEUN JEONG
5UltraV Co., Ltd. Research Center, Seoul, Republic of Korea;
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HAN JIN KWON
5UltraV Co., Ltd. Research Center, Seoul, Republic of Korea;
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CHAN-YEONG HEO
1Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;
2Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea;
3Korean Skin Research Center, Seongnam, Republic of Korea;
4H&BIO Corporation/R&D Center, Seongnam, Republic of Korea;
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  • For correspondence: lionheo{at}snu.ac.kr
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Figures

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  • Figure 1.
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    Figure 1.

    Particle morphology of fillers.

  • Figure 2.
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    Figure 2.

    Images of the skin after in vivo administration. (A) Surface of the skin following in vivo administration of the fillers. (B) Images of the skin at 4 and 12 weeks after in vivo administration. Images were obtained using Folliscope (LeedM, Seoul, Republic of Korea) at a magnification of 15×.

  • Figure 3.
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    Figure 3.

    The evaluation of filler’s durability. Analysis of changes in filler volume. Data were obtained by using Primos-LITE Topography (with Software PRIMOS 5.6, Tests of Normality; Shapiro-Wilk, Test of Homogeneity of Variances; Levene Statistic).

  • Figure 4.
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    Figure 4.

    Changes of (A) epidermal thickness (original magnification of 12.6×) and (B) dermal collagen fibres (original magnification of 100×).

  • Figure 5.
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    Figure 5.

    The Sirius red positive area indicating collagen deposition around the filler (original magnification of 100×).

  • Figure 6.
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    Figure 6.

    Analysis of Sirius red positive area indicating collagen deposition around the filler.

  • Figure 7.
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    Figure 7.

    Improvement of dermal density, wrinkles, and skin radiance of PDO filler.

  • Figure 8.
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    Figure 8.

    Images of dermal density taken using a DUB® skin scanner (EOTECH SA).

  • Figure 9.
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    Figure 9.

    Images taken by using Antera 3D CS (Miravex Limited) showing changes in wrinkles on the face (A) and the canthus skin (B).

  • Figure 10.
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    Figure 10.

    The evaluation of skin gloss. Images taken by using Mark-Vu (PSI Plus Co., Ltd.) showing changes in skin radiance on the face (A) and the canthus skin (B).

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In Vivo: 37 (3)
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May-June 2023
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Bio-characteristics and Efficacy Analysis of Biodegradable Poly Dioxanone Dermal Filler in a Mouse Model and Humans
SHU-YI ZHOU, SO MIN KANG, YEON JU GU, XIN RUI ZHANG, DONG KEON YON, BYUNG HO SHIN, JUNG RYUL HAM, WON KU LEE, JE GEUN JEONG, HAN JIN KWON, CHAN-YEONG HEO
In Vivo May 2023, 37 (3) 1093-1102; DOI: 10.21873/invivo.13184

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Bio-characteristics and Efficacy Analysis of Biodegradable Poly Dioxanone Dermal Filler in a Mouse Model and Humans
SHU-YI ZHOU, SO MIN KANG, YEON JU GU, XIN RUI ZHANG, DONG KEON YON, BYUNG HO SHIN, JUNG RYUL HAM, WON KU LEE, JE GEUN JEONG, HAN JIN KWON, CHAN-YEONG HEO
In Vivo May 2023, 37 (3) 1093-1102; DOI: 10.21873/invivo.13184
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Keywords

  • Polydioxanone
  • polycaprolactone
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