Figure 4. Chemosensitizing effect of wilforlide A (WA) to PC3-TxR and DU145-TxR cell lines, the corresponding resistant cell lines to docetaxel (Dtx). (A) PC3-TxR cell line (IC50D: 21.5±1.6 nM, IC50HD: 13.8, 8.8, 5.8 and 2.9 nM in presence of WA at concentrations of 0.625, 1.25, 2.5 and 5.0 μg/ml); (B) DU145-TxR cell line (IC50D: >1,000 nM, IC50HD: 990.9, 242.6, 124.2 and 48.54 nM in presence of WA at concentrations of 0.625, 1.25, 2.5 and 5.0 μg/ml); (C) PC3 cell line (IC50D: 1.86±0.12 nM, IC50HD: 1.45, 1.45, and 1.61 nM in presence of WA at concentrations of 0.625, 1.25, and 2.5 μg/ml); (D) DU145 cell line (IC50D: 1.177 nM, IC50HD: 1.012, 0.866, and 0.748 nM in presence of WA at concentrations of 0.625, 1.25, and 2.5 μg/ml); (E) HPrEpC cells (IC50D: 1.307 nM, IC50HD: 1.26 nM).