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Research ArticleExperimental Studies
Open Access

Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML

DANIEL H. ALBERT, NEAL C. GOODWIN, ANGELA M. DAVIES, JENNY ROWE, GEROLD FEUER, MICHAEL BOYIADZIS, KATHLEEN A. DORRITIE, MARIA MANCINI, REGINA GANDOUR-EDWARDS, BRIAN A. JONAS, GAUTAM BORTHAKUR, IBRAHIM ALDOSS, DAVID A. RIZZIERI, OLATOYOSI ODENIKE, THOMAS PREBET, SANJANA SINGH, RELJA POPOVIC, YU SHEN, KEITH F. MCDANIEL, WARREN M. KATI, DIMPLE A. MODI, MONICA MOTWANI, JOHANNES E. WOLFF and DAVID J. FROST
In Vivo July 2022, 36 (4) 1615-1627; DOI: https://doi.org/10.21873/invivo.12872
DANIEL H. ALBERT
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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  • For correspondence: daniel.h.albert{at}abbvie.com
NEAL C. GOODWIN
2Champions Oncology, Inc., Hackensack, NJ, U.S.A.;
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ANGELA M. DAVIES
2Champions Oncology, Inc., Hackensack, NJ, U.S.A.;
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JENNY ROWE
3HuMurine Technologies, La Verne, CA, U.S.A.;
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GEROLD FEUER
3HuMurine Technologies, La Verne, CA, U.S.A.;
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MICHAEL BOYIADZIS
4University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA, U.S.A.;
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KATHLEEN A. DORRITIE
4University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA, U.S.A.;
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MARIA MANCINI
2Champions Oncology, Inc., Hackensack, NJ, U.S.A.;
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REGINA GANDOUR-EDWARDS
5Department of Pathology & Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA, U.S.A.;
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BRIAN A. JONAS
6University of California Davis School of Medicine, Sacramento, CA, U.S.A.;
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GAUTAM BORTHAKUR
7Department of Leukemia, The University of Texas MD Anderson, Houston, TX, U.S.A.;
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IBRAHIM ALDOSS
8Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, U.S.A.;
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DAVID A. RIZZIERI
9Medical Oncology, Novant Health Cancer Institute, Charlotte, NC, U.S.A.;
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OLATOYOSI ODENIKE
10Section of Hematology/Oncology, The University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, U.S.A.;
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THOMAS PREBET
11Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT, U.S.A.
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SANJANA SINGH
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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RELJA POPOVIC
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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YU SHEN
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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KEITH F. MCDANIEL
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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WARREN M. KATI
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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DIMPLE A. MODI
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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MONICA MOTWANI
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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JOHANNES E. WOLFF
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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DAVID J. FROST
1AbbVie, Inc., North Chicago, IL, U.S.A.;
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Article Information

vol. 36 no. 4 1615-1627
DOI 
https://doi.org/10.21873/invivo.12872
PMID 
35738590

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received May 3, 2022
  • Revision received May 13, 2022
  • Accepted May 16, 2022
  • Published online June 23, 2022.

Copyright & License 
Copyright © 2022 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. DANIEL H. ALBERT1⇑,
  2. NEAL C. GOODWIN2,
  3. ANGELA M. DAVIES2,
  4. JENNY ROWE3,
  5. GEROLD FEUER3,
  6. MICHAEL BOYIADZIS4,
  7. KATHLEEN A. DORRITIE4,
  8. MARIA MANCINI2,
  9. REGINA GANDOUR-EDWARDS5,
  10. BRIAN A. JONAS6,
  11. GAUTAM BORTHAKUR7,
  12. IBRAHIM ALDOSS8,
  13. DAVID A. RIZZIERI9,
  14. OLATOYOSI ODENIKE10,
  15. THOMAS PREBET11,
  16. SANJANA SINGH1,
  17. RELJA POPOVIC1,
  18. YU SHEN1,
  19. KEITH F. MCDANIEL1,
  20. WARREN M. KATI1,
  21. DIMPLE A. MODI1,
  22. MONICA MOTWANI1,
  23. JOHANNES E. WOLFF1 and
  24. DAVID J. FROST1
  1. 1AbbVie, Inc., North Chicago, IL, U.S.A.;
  2. 2Champions Oncology, Inc., Hackensack, NJ, U.S.A.;
  3. 3HuMurine Technologies, La Verne, CA, U.S.A.;
  4. 4University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA, U.S.A.;
  5. 5Department of Pathology & Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA, U.S.A.;
  6. 6University of California Davis School of Medicine, Sacramento, CA, U.S.A.;
  7. 7Department of Leukemia, The University of Texas MD Anderson, Houston, TX, U.S.A.;
  8. 8Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, U.S.A.;
  9. 9Medical Oncology, Novant Health Cancer Institute, Charlotte, NC, U.S.A.;
  10. 10Section of Hematology/Oncology, The University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, U.S.A.;
  11. 11Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT, U.S.A.
  1. Correspondence to: Daniel H. Albert, Dept. R4N2, Bldg. AP3, Rm. 316, 1 North Waukegan Road, North Chicago, IL 60064-6098, U.S.A. Tel: +1 8479373844, Fax: +1 8479383266, e-mail: daniel.h.albert{at}abbvie.com
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Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML
DANIEL H. ALBERT, NEAL C. GOODWIN, ANGELA M. DAVIES, JENNY ROWE, GEROLD FEUER, MICHAEL BOYIADZIS, KATHLEEN A. DORRITIE, MARIA MANCINI, REGINA GANDOUR-EDWARDS, BRIAN A. JONAS, GAUTAM BORTHAKUR, IBRAHIM ALDOSS, DAVID A. RIZZIERI, OLATOYOSI ODENIKE, THOMAS PREBET, SANJANA SINGH, RELJA POPOVIC, YU SHEN, KEITH F. MCDANIEL, WARREN M. KATI, DIMPLE A. MODI, MONICA MOTWANI, JOHANNES E. WOLFF, DAVID J. FROST
In Vivo Jul 2022, 36 (4) 1615-1627; DOI: 10.21873/invivo.12872

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Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML
DANIEL H. ALBERT, NEAL C. GOODWIN, ANGELA M. DAVIES, JENNY ROWE, GEROLD FEUER, MICHAEL BOYIADZIS, KATHLEEN A. DORRITIE, MARIA MANCINI, REGINA GANDOUR-EDWARDS, BRIAN A. JONAS, GAUTAM BORTHAKUR, IBRAHIM ALDOSS, DAVID A. RIZZIERI, OLATOYOSI ODENIKE, THOMAS PREBET, SANJANA SINGH, RELJA POPOVIC, YU SHEN, KEITH F. MCDANIEL, WARREN M. KATI, DIMPLE A. MODI, MONICA MOTWANI, JOHANNES E. WOLFF, DAVID J. FROST
In Vivo Jul 2022, 36 (4) 1615-1627; DOI: 10.21873/invivo.12872
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