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Research ArticleClinical Studies

Plasma Concentration of the Lipid Peroxidation (LP) Biomarker 4-Ηydroxynonenal (4-HNE) in Benign and Cancer Patients

MAARET ESKELINEN, IINA SAIMANEN, RIIKA KOSKELA, ANU HOLOPAINEN, TUOMAS SELANDER and MATTI ESKELINEN
In Vivo March 2022, 36 (2) 773-779; DOI: https://doi.org/10.21873/invivo.12764
MAARET ESKELINEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland;
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  • For correspondence: matti.eskelinen{at}kuh.fi
IINA SAIMANEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland;
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RIIKA KOSKELA
2Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland;
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ANU HOLOPAINEN
3Department of Clinical Chemistry, Eastern Finland Laboratory Center, Kuopio University Hospital, Kuopio, Finland;
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TUOMAS SELANDER
4Science Service Center, Kuopio University Hospital, Kuopio, Finland
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MATTI ESKELINEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland;
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    Figure 1.

    Study flowchart.

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    Figure 2.

    Plasma median 4-hydroxynonenal (4-HNE) concentrations in benign and cancer patients preoperatively, immediately after operation and 24 h after operation. p≤0.001 using the Wilcoxon signed-rank test.

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    Figure 3.

    Plasma malonidialdehyde (MDA) concentrations versus plasma 4-hydroxynonenal (4-HNE) concentrations in benign and cancer patients shown as Jitterplot. Spearman’s r=0.413, p<0.001).

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In Vivo
Vol. 36, Issue 2
March-April 2022
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Plasma Concentration of the Lipid Peroxidation (LP) Biomarker 4-Ηydroxynonenal (4-HNE) in Benign and Cancer Patients
MAARET ESKELINEN, IINA SAIMANEN, RIIKA KOSKELA, ANU HOLOPAINEN, TUOMAS SELANDER, MATTI ESKELINEN
In Vivo Mar 2022, 36 (2) 773-779; DOI: 10.21873/invivo.12764

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Plasma Concentration of the Lipid Peroxidation (LP) Biomarker 4-Ηydroxynonenal (4-HNE) in Benign and Cancer Patients
MAARET ESKELINEN, IINA SAIMANEN, RIIKA KOSKELA, ANU HOLOPAINEN, TUOMAS SELANDER, MATTI ESKELINEN
In Vivo Mar 2022, 36 (2) 773-779; DOI: 10.21873/invivo.12764
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Keywords

  • Benign disease
  • cancer
  • lipid peroxidation
  • plasma 4-hydroxynonenal
  • pain score following surgery
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