Article Figures & Data
Figures
- Figure 1.
Western blot showing a minimal level of expression of mucin-5AC on the normal pancreas but high levels of expression in a primary patient-derived pancreatic tumor, AA1305, and a patient-derived liver metastasis from a primary pancreatic cancer (PancMet).
- Figure 2.
Imaging of subcutaneous models 72 h after injection with 50 μg (A) and 75 μg (B) mucin-5AC monoclonal antibody conjugated to the near-infrared dye IRDye800CW.
- Figure 3.
Patient-derived orthotopic xenograft (PDOX) model of AA1305 72 h after injection of 75 μg of mucin 5AC (MUC5-AC) monoclonal antibody conjugated to the near-infrared dye IRDye800CW. The implanted pancreatic tumor (black arrow) brightly fluoresced compared to normal pancreas surrounding it (yellow arrow). There is also a fluorescence signal from local tumor invasion on the abdominal wall (white arrow) where the peritoneum overlaid the pancreas, as well as fluorescence on the mouse’s stomach (red arrow). The fluorescence on the stomach does not represent metastatic spread but normal MUC5AC expression, possibly also fluorescence of the mouse chow.
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