Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft

MICHAEL A. TURNER; HANNAH M. HOLLANDSWORTH; HIROTO NISHINO; SIAMAK AMIRFAKHRI; THINZAR M. LWIN; ANDREW M. LOWY; SUKHWINDER KAUR; GOPALAKRISHNAN NATARAJAN; KAVITA MALLYA; ROBERT M. HOFFMAN; SURINDER K. BATRA; MICHAEL BOUVET

doi:10.21873/invivo.12676

Research ArticleExperimental Studies

Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft

MICHAEL A. TURNER, HANNAH M. HOLLANDSWORTH, HIROTO NISHINO, SIAMAK AMIRFAKHRI, THINZAR M. LWIN, ANDREW M. LOWY, SUKHWINDER KAUR, GOPALAKRISHNAN NATARAJAN, KAVITA MALLYA, ROBERT M. HOFFMAN, SURINDER K. BATRA and MICHAEL BOUVET

In Vivo January 2022, 36 (1) 57-62; DOI: https://doi.org/10.21873/invivo.12676

MICHAEL A. TURNER

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

2VA San Diego Healthcare System, San Diego, CA, U.S.A.;

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HANNAH M. HOLLANDSWORTH

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

2VA San Diego Healthcare System, San Diego, CA, U.S.A.;

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HIROTO NISHINO

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

2VA San Diego Healthcare System, San Diego, CA, U.S.A.;

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SIAMAK AMIRFAKHRI

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

2VA San Diego Healthcare System, San Diego, CA, U.S.A.;

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THINZAR M. LWIN

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

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ANDREW M. LOWY

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

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SUKHWINDER KAUR

3Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, U.S.A.;

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GOPALAKRISHNAN NATARAJAN

3Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, U.S.A.;

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KAVITA MALLYA

3Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, U.S.A.;

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ROBERT M. HOFFMAN

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

2VA San Diego Healthcare System, San Diego, CA, U.S.A.;

4AntiCancer, Inc., San Diego, CA, U.S.A.

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SURINDER K. BATRA

3Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, U.S.A.;

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MICHAEL BOUVET

1Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;

2VA San Diego Healthcare System, San Diego, CA, U.S.A.;

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For correspondence: mbouvet{at}ucsd.edu

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vol. 36 no. 1 57-62

DOI

https://doi.org/10.21873/invivo.12676

PMID

34972700

Published By

International Institute of Anticancer Research

Print ISSN

0258-851X

Online ISSN

1791-7549

History

Received September 27, 2021
Revision received October 23, 2021
Accepted October 27, 2021
Published online December 30, 2021.

Author Information

MICHAEL A. TURNER¹,²,
HANNAH M. HOLLANDSWORTH¹,²,
HIROTO NISHINO¹,²,
SIAMAK AMIRFAKHRI¹,²,
THINZAR M. LWIN¹,
ANDREW M. LOWY¹,
SUKHWINDER KAUR³,
GOPALAKRISHNAN NATARAJAN³,
KAVITA MALLYA³,
ROBERT M. HOFFMAN¹,²,⁴,
SURINDER K. BATRA³ and
MICHAEL BOUVET¹,² ⇑

¹Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.;
²VA San Diego Healthcare System, San Diego, CA, U.S.A.;
³Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, U.S.A.;
⁴AntiCancer, Inc., San Diego, CA, U.S.A.

Correspondence to: Michael Bouvet, MD, UCSD Moores Cancer Center, 3855 Health Sciences Drive #0987, La Jolla, CA 92093-0987, U.S.A. Tel: +1 8588226191, Fax: +1 8588226192, e-mail: mbouvet{at}ucsd.edu

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Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft

In Vivo Jan 2022, 36 (1) 57-62; DOI: 10.21873/invivo.12676

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Keywords

Pancreatic cancer
mucin
MUC5AC
antibody
tumor-specific imaging
fluorescence guided surgery
PDOX

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