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Research ArticleExperimental Studies

Influence of Radiation Dose and Reconstruction Kernel on Fat Fraction Analysis in Dual-energy CT: A Phantom Study

VASILIKI CHATZARAKI, CORINNA BORN, RAHEL A. KUBIK-HUCH, JOHANNES M. FROEHLICH, MICHAEL J. THALI and TILO NIEMANN
In Vivo November 2021, 35 (6) 3147-3155; DOI: https://doi.org/10.21873/invivo.12609
VASILIKI CHATZARAKI
1Department of Radiology, Kantonsspital Baden, Baden, Switzerland;
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CORINNA BORN
2Hospital Pharmacy, Kantonsspital Baden, Baden, Switzerland;
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RAHEL A. KUBIK-HUCH
1Department of Radiology, Kantonsspital Baden, Baden, Switzerland;
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JOHANNES M. FROEHLICH
3Guerbet AG, Zurich, Switzerland;
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MICHAEL J. THALI
4Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland
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TILO NIEMANN
1Department of Radiology, Kantonsspital Baden, Baden, Switzerland;
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  • For correspondence: tilo.niemann{at}ksb.ch
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    Figure 1.

    Six fat-containing probes with fat concentrations varying from 0% to 100% with increments of 20% were prepared.

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    Figure 2.

    Hounsfield units (HU), image noise (HU-stadard deviation) and fat fraction measurements of the 0% probe: measurement in syngo.via demonstration placement of regions of interest and available results.

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    Figure 3.

    Clustered scatter plots showing the fat fraction (FF) measured in dual energy CT (DECT) [FF – DECT (%)] vs. the actual fat concentration of the phantom probes (%) using the three reconstruction kernels. Each spot represents the FF value measured at different radiation doses (mAs).

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    Figure 4.

    Bland-Altman plots depicting the variation of the difference and the absolute difference between fat fraction and actual fat concentrations (averaged over all fat probes and reconstruction kernels) vs. the different radiation dose levels applied. The black thick horizontal lines represent the mean values (averaged over all radiation dose levels).

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Vol. 35, Issue 6
November-December 2021
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Influence of Radiation Dose and Reconstruction Kernel on Fat Fraction Analysis in Dual-energy CT: A Phantom Study
VASILIKI CHATZARAKI, CORINNA BORN, RAHEL A. KUBIK-HUCH, JOHANNES M. FROEHLICH, MICHAEL J. THALI, TILO NIEMANN
In Vivo Nov 2021, 35 (6) 3147-3155; DOI: 10.21873/invivo.12609

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Influence of Radiation Dose and Reconstruction Kernel on Fat Fraction Analysis in Dual-energy CT: A Phantom Study
VASILIKI CHATZARAKI, CORINNA BORN, RAHEL A. KUBIK-HUCH, JOHANNES M. FROEHLICH, MICHAEL J. THALI, TILO NIEMANN
In Vivo Nov 2021, 35 (6) 3147-3155; DOI: 10.21873/invivo.12609
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Keywords

  • dual-energy computed tomography
  • fat fraction
  • radiation dose
  • reconstruction kernel
  • photon energy
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