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Research ArticleExperimental Studies

The Effects of Trypsin Inhibitor on Insulin Secretion Using Rat Pancreas in an Organ Bath

ASUKA MORITA, MOTOSHI OUCHI, KEITARO SATOH, SHUNSUKE KOBAYASHI, MISAO TERADA, HIDEFUMI WAKASHIN, HIROE KON, KEITARO HAYASHI, NAOHIKO ANZAI, AKIRA SHIMIZU, HITOSHI SUGIHARA, KENZO OBA and TOMOE FUJITA
In Vivo September 2021, 35 (5) 2551-2558; DOI: https://doi.org/10.21873/invivo.12537
ASUKA MORITA
1Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan;
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MOTOSHI OUCHI
1Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan;
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  • For correspondence: ouchi{at}dokkyomed.ac.jp
KEITARO SATOH
2Department of Pharmacology, Meikai University School of Dentistry, Saitama, Japan;
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SHUNSUKE KOBAYASHI
3Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan;
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MISAO TERADA
4Dokkyo Medical University School of Medicine, Tochigi, Japan;
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HIDEFUMI WAKASHIN
5Department of Regulatory Physiology, Dokkyo Medical University School of Medicine, Tochigi, Japan;
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HIROE KON
6Research Center for Laboratory Animals, Dokkyo Medical University, Tochigi, Japan;
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KEITARO HAYASHI
1Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan;
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NAOHIKO ANZAI
4Dokkyo Medical University School of Medicine, Tochigi, Japan;
7Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan;
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AKIRA SHIMIZU
8Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan;
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HITOSHI SUGIHARA
3Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan;
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KENZO OBA
9Kawaguchi Sakura Clinic, Saitama, Japan
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TOMOE FUJITA
1Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan;
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Article Information

vol. 35 no. 5 2551-2558
DOI 
https://doi.org/10.21873/invivo.12537
PMID 
34410942

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received May 3, 2021
  • Revision received May 31, 2021
  • Accepted June 1, 2021
  • Published online August 17, 2021.

Copyright & License 
Copyright © 2021 The Author(s). Published by the International Institute of Anticancer Research.

Author Information

  1. ASUKA MORITA1,*,
  2. MOTOSHI OUCHI1,*⇑,
  3. KEITARO SATOH2,
  4. SHUNSUKE KOBAYASHI3,
  5. MISAO TERADA4,
  6. HIDEFUMI WAKASHIN5,
  7. HIROE KON6,
  8. KEITARO HAYASHI1,
  9. NAOHIKO ANZAI4,7,
  10. AKIRA SHIMIZU8,
  11. HITOSHI SUGIHARA3,
  12. KENZO OBA9 and
  13. TOMOE FUJITA1
  1. 1Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan;
  2. 2Department of Pharmacology, Meikai University School of Dentistry, Saitama, Japan;
  3. 3Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan;
  4. 4Dokkyo Medical University School of Medicine, Tochigi, Japan;
  5. 5Department of Regulatory Physiology, Dokkyo Medical University School of Medicine, Tochigi, Japan;
  6. 6Research Center for Laboratory Animals, Dokkyo Medical University, Tochigi, Japan;
  7. 7Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan;
  8. 8Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan;
  9. 9Kawaguchi Sakura Clinic, Saitama, Japan
  1. Correspondence to: Motoshi Ouchi, MD, Ph.D., Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan. E-mail: ouchi{at}dokkyomed.ac.jp
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The Effects of Trypsin Inhibitor on Insulin Secretion Using Rat Pancreas in an Organ Bath
ASUKA MORITA, MOTOSHI OUCHI, KEITARO SATOH, SHUNSUKE KOBAYASHI, MISAO TERADA, HIDEFUMI WAKASHIN, HIROE KON, KEITARO HAYASHI, NAOHIKO ANZAI, AKIRA SHIMIZU, HITOSHI SUGIHARA, KENZO OBA, TOMOE FUJITA
In Vivo Sep 2021, 35 (5) 2551-2558; DOI: 10.21873/invivo.12537

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The Effects of Trypsin Inhibitor on Insulin Secretion Using Rat Pancreas in an Organ Bath
ASUKA MORITA, MOTOSHI OUCHI, KEITARO SATOH, SHUNSUKE KOBAYASHI, MISAO TERADA, HIDEFUMI WAKASHIN, HIROE KON, KEITARO HAYASHI, NAOHIKO ANZAI, AKIRA SHIMIZU, HITOSHI SUGIHARA, KENZO OBA, TOMOE FUJITA
In Vivo Sep 2021, 35 (5) 2551-2558; DOI: 10.21873/invivo.12537
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Keywords

  • insulin
  • amylase
  • pancreas
  • trypsin inhibitor
  • organ bath
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