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Research ArticleExperimental Studies

Efficacy of Oral Recombinant Methioninase and Eribulin on a PDOX Model of Triple-negative Breast Cancer (TNBC) Liver Metastasis

HYE IN LIM, YU SUN, QINGHONG HAN, JUN YAMAMOTO and ROBERT M. HOFFMAN
In Vivo September 2021, 35 (5) 2531-2534; DOI: https://doi.org/10.21873/invivo.12534
HYE IN LIM
1AntiCancer Inc, San Diego, CA, U.S.A.;
2Department of Surgery, University of California, San Diego, CA, U.S.A.;
3Department of Surgery, Chinjujeil Hospital, Jinju, Republic of Korea
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  • For correspondence: vastprogress{at}naver.com
YU SUN
1AntiCancer Inc, San Diego, CA, U.S.A.;
2Department of Surgery, University of California, San Diego, CA, U.S.A.;
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QINGHONG HAN
1AntiCancer Inc, San Diego, CA, U.S.A.;
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JUN YAMAMOTO
1AntiCancer Inc, San Diego, CA, U.S.A.;
2Department of Surgery, University of California, San Diego, CA, U.S.A.;
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ROBERT M. HOFFMAN
1AntiCancer Inc, San Diego, CA, U.S.A.;
2Department of Surgery, University of California, San Diego, CA, U.S.A.;
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  • For correspondence: all{at}anticancer.com
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Article Information

vol. 35 no. 5 2531-2534
DOI 
https://doi.org/10.21873/invivo.12534
PMID 
34410939

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received October 23, 2020
  • Revision received July 12, 2021
  • Accepted July 15, 2021
  • Published online August 17, 2021.

Copyright & License 
Copyright © 2021 The Author(s). Published by the International Institute of Anticancer Research.

Author Information

  1. HYE IN LIM1,2,3⇑,
  2. YU SUN1,2,
  3. QINGHONG HAN1,
  4. JUN YAMAMOTO1,2 and
  5. ROBERT M. HOFFMAN1,2⇑
  1. 1AntiCancer Inc, San Diego, CA, U.S.A.;
  2. 2Department of Surgery, University of California, San Diego, CA, U.S.A.;
  3. 3Department of Surgery, Chinjujeil Hospital, Jinju, Republic of Korea
  1. Correspondence to: Hye In Lim, Department of Surgery, Chinjujeil Hospital, Jinju, Republic of Korea. Tel: +82 1099330009, e-mail: vastprogress{at}naver.com
  2. Correspondence to: Robert M. Hoffman, AntiCancer, Inc, 7917 Ostrow St, San Diego, CA, 92111, U.S.A. Tel: +1 8586542555, e-mail: all{at}anticancer.com
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Efficacy of Oral Recombinant Methioninase and Eribulin on a PDOX Model of Triple-negative Breast Cancer (TNBC) Liver Metastasis
HYE IN LIM, YU SUN, QINGHONG HAN, JUN YAMAMOTO, ROBERT M. HOFFMAN
In Vivo Sep 2021, 35 (5) 2531-2534; DOI: 10.21873/invivo.12534

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Efficacy of Oral Recombinant Methioninase and Eribulin on a PDOX Model of Triple-negative Breast Cancer (TNBC) Liver Metastasis
HYE IN LIM, YU SUN, QINGHONG HAN, JUN YAMAMOTO, ROBERT M. HOFFMAN
In Vivo Sep 2021, 35 (5) 2531-2534; DOI: 10.21873/invivo.12534
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  • Immunohistochemical Evaluation of Tumor Characteristic Retention in Triple-negative Breast Cancer PDOX Models
  • Engineered Methioninase-expressing Tumor-targeting Salmonella typhimurium A1-R Inhibits Syngeneic-Cancer Mouse Models by Depleting Tumor Methionine
  • Recombinant Methioninase (rMETase) Synergistically Sensitizes Ivermectin-resistant MCF-7 Breast Cancer Cells 9.9 Fold to Low-dose Ivermectin
  • Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem
  • Recombinant Methioninase Increases Eribulin Efficacy 16-fold in Highly Eribulin-resistant HT1080 Fibrosarcoma Cells, Demonstrating Potential to Overcome the Clinical Challenge of Drug-resistant Soft-tissue Sarcoma
  • [11C]Methionine PET vs. [18F]Fluorodeoxyglucose PET Whole-body Imaging to Determine the Extent of Methionine-addiction Compared to Glucose-addiction of Primary and Metastatic Cancer of the Trunk in Patients
  • Recombinant Methioninase Is Selectively Synergistic With Doxorubicin Against Wild-type Fibrosarcoma Cells Compared to Normal Cells and Overcomes Highly-Doxorubicin-resistant Fibrosarcoma
  • Induction of the DNA-Repair Gene POLQ only in BRCA1-mutant Breast-Cancer Cells by Methionine Restriction
  • DNA-Binding Agent Trabectedin Combined With Recombinant Methioninase Is Synergistic to Decrease Fibrosarcoma Cell Viability and Induce Nuclear Fragmentation But Not Synergistic on Normal Fibroblasts
  • Reduction of Tumor Biomarkers from very High to Normal and Extensive Metastatic Lesions to Undetectability in a Patient With Stage IV HER2-positive Breast Cancer Treated With Low-dose Trastuzumab Deruxtecan in Combination With Oral Recombinant Methioninase and a Low-methionine Diet
  • Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts
  • [11C] Methionine-PET Imaging as a Cancer Biomarker for Methionine Addiction and Sensitivity to Methionine-restriction-based Combination Chemotherapy
  • Elimination of Axillary-Lymph-Node Metastases in a Patient With Invasive Lobular Breast Cancer Treated by First-line Neo-adjuvant Chemotherapy Combined With Methionine Restriction
  • Oral Installation of Recombinant Methioninase-producing Escherichia coli into the Microbiome Inhibits Colon-cancer Growth in a Syngeneic Mouse Model
  • Clinicopathological and Prognostic Significance of Programmed Death Ligand-1 SP142 Expression in 132 Patients With Triple-negative Breast Cancer
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Keywords

  • Triple negative breast cancer
  • TNBC
  • patient-derived orthotopic xenograft
  • PDOX
  • liver metastasis
  • Eribulin
  • oral recombinant methioninase
  • o-rMETase
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