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Research ArticleExperimental Studies

Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer

KAROLINA BANYS, JOANNA GIEBULTOWICZ, MARCIN SOBCZAK, RAFAL WYREBIAK, WOJCIECH BIELECKI, ROBERT WRZESIEN and BARBARA BOBROWSKA-KORCZAK
In Vivo July 2021, 35 (4) 2059-2072; DOI: https://doi.org/10.21873/invivo.12475
KAROLINA BANYS
1Department of Bromatology, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland;
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JOANNA GIEBULTOWICZ
2Department of Drug Analysis, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland;
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MARCIN SOBCZAK
3Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland;
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RAFAL WYREBIAK
3Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland;
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WOJCIECH BIELECKI
4Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Live Sciences, Warsaw, Poland;
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ROBERT WRZESIEN
5Central Laboratory of Experimental Animals, Medical University of Warsaw, Warsaw, Poland
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BARBARA BOBROWSKA-KORCZAK
1Department of Bromatology, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland;
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  • For correspondence: barbara.bobrowska@wum.edu.pl
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Abstract

Background/Aim: The aim of the study was to assess the impact of nano-, micro-, and macro-sized-genistein on the growth and development of neoplasms in rats with mammary cancer. Additionally, the effect on the kinetics of changes (9-11-17-20 week of a rat’s life) in the levels of methyl derivatives: 1-methyladenine, 3-methyladenine, 7-methylguanine, 1-methylguanine, 1-methyladenosine, 7-methylguanosine, O-methyl-guanosine and N6-methyl-2’-deoxyguanosine in the urine of rats was analyzed. Materials and Methods: Female Sprague-Dawley rats divided into 4 groups were used in the study. Animals were fed only a control diet or diets supplemented with the nano-, micro- and macro-sized genistein. To induce the mammary adenocarcinoma, rats were treated with 7,12-dimethylbenz[a]anthracene (DMBA). Modified nucleosides were determined by a high-performance liquid chromatography coupled to mass spectrometry method (LC-MS/MS). Results: The supplementation of the diet of animals with genistein resulted in an increase in the excretion of methylated derivatives in the urine of rats. In the animals receiving standard diet, the levels of methyl derivatives increased during the study or remained relatively low. In the case of animals whose diet was supplemented with the various forms of genistein, the levels of methylated derivatives were very high from the beginning. Conclusion: High levels of methyl derivatives can influence carcinogenesis.

  • Genistein
  • nanoparticles
  • macroparticles
  • Received March 26, 2021.
  • Revision received April 22, 2021.
  • Accepted April 23, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer
KAROLINA BANYS, JOANNA GIEBULTOWICZ, MARCIN SOBCZAK, RAFAL WYREBIAK, WOJCIECH BIELECKI, ROBERT WRZESIEN, BARBARA BOBROWSKA-KORCZAK
In Vivo Jul 2021, 35 (4) 2059-2072; DOI: 10.21873/invivo.12475

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Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer
KAROLINA BANYS, JOANNA GIEBULTOWICZ, MARCIN SOBCZAK, RAFAL WYREBIAK, WOJCIECH BIELECKI, ROBERT WRZESIEN, BARBARA BOBROWSKA-KORCZAK
In Vivo Jul 2021, 35 (4) 2059-2072; DOI: 10.21873/invivo.12475
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Keywords

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