Abstract
Background/Aim: Chitinase 3-like 1 (CHI3L1) is overexpressed in asthma, and negatively associated with forced expiratory volume in the first second. This study aimed at evaluating whether CHI3L1 genotypes affect asthma risk. Materials and Methods: The blood samples of 198 asthma patients and 453 control subjects were collected, and the genotypic patterns of CHI3L1 -131C/G (rs4950928) and -247G/A (rs1262491437) were examined. Results: The percentages of CG and GG at CHI3L1 -131C/G were 32.8% and 7.6% among the asthma cases, respectively, significantly higher than the 23.8% and 3.1% among the non-asthmatic healthy subjects (p for trend=0.0009). The allelic frequency distribution analysis showed that the G allele at CHI3L1 - 131C/G conferred a significantly higher asthma risk than the wild-type C allele (p<0.0001). The genotypic and allelic frequency analyses for CHI3L1 -247G/A did not show any significant difference. Conclusion: The G allele at CHI3L1-131C/G serves as a biomarker in determining personal susceptibility to asthma in Taiwan.
Footnotes
Authors’ Contributions
Research design: Chen CL and Wang SC; patient and questionnaire summaries: Chen CL, Shen TC and Hsia TC; experimental work: Chang WS and Tsai CW; statistical analysis: Wang SC, Lin C and Chang WS; article writing: Tsai CW and Bau DT; review and revision: Tsai CW and Bau DT.
This article is freely accessible online.
Funding
This study was supported mainly by Taichung Armed Forces General Hospital (TCAFGH-D-109012) to Dr. Chen and partially by the China Medical University Hospital (DMR-110-181) to Dr. Tsai.
Conflicts of Interest
All the Authors have declared no conflicts of interest in relation to this study.
- Received January 9, 2021.
- Revision received January 24, 2021.
- Accepted January 25, 2021.
- Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved