Figure 2. Effect of combination therapy for mice with transplanted SCCKN cells. (A) Kaplan-Meier survival curves of mice in the control group (solid line, n=4), CDDP treatment group (chain line, n=4) and CDDP+E3C1 treatment group (dashed line, n=4) (control vs. CDDP, p<0.05; control vs. CDDP+E3C1, p<0.05; CDDP vs. CDDP+E3C1, p<0.05). (B-D) Chronological changes in tumor volume in individual mice following control (B), CDDP treatment (C) and CDDP+E3C1 treatment (D). (E) After 11 days of treatment, comparison of tumor volumes (control vs. CDDP+E3C1, p<0.05; CDDP vs. CDDP+E3C1, p<0.05). (F) After 11 days of treatment, comparison of mouse weights (control vs. CDDP, p<0.01; control vs. CDDP+E3C1, p<0.05; CDDP vs. CDDP+E3C1, p<0.01). Results are expressed as mean±SD (E, F).