Abstract
Background/Aim: We aimed to elucidate the prognostic impact of tumor doubling time (DT) and radical surgery when classified by DT in patients with metachronous liver, lung, or peritoneal metastases of colorectal cancer (CRC). Patients and Methods: We reviewed the data of 1941 patients who underwent curative surgery for CRC and calculated DT for recurrences using computed tomography. Results: Short DT was an independent prognostic risk factor in liver (p<0.001) and peritoneal (p=0.03) metastases. Survival was significantly better in patients who underwent surgery than in those who did not, both in short and long DT groups in any metastatic organ (p<0.01). Patients with long DT gained significantly better prognostic benefit from surgery than those with short DT in liver (p=0.01) and peritoneal (p=0.04) metastases. Conclusion: Surgery is recommended for resectable metastases, especially in patients with liver and peritoneal metastases with long DT.
Footnotes
Authors' Contributions
Hiroaki Miyake acquired the data, established the study design and concept, analyzed the data, and drafted the article. Koji Murono interpreted the data and revised the article. Kazushige Kawai acquired the data and revised the article. Soichiro Ishihara, Hiroaki Nozawa, Harufumi Maki, Kiyoshi Hasegawa, and Jun Nakajima revised the article. All Authors have approved the final version of the manuscript.
This article is freely accessible online.
Funding
The study was partly supported from the Japan Agency for Medical Research and Development (grant number: JP19cm0106502) and from the Japan Society for the Promotion of Science (grant numbers: 19K09115, 19K09114, 18K07194, 17K10623, 17K10621, and 17K10620).
Conflicts of Interest
There are no conflicts of interest to declare regarding this study.
- Received September 8, 2020.
- Revision received September 19, 2020.
- Accepted September 20, 2020.
- Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved