Abstract
Background/Aim: The in vivo effect of abiraterone on bone mineral density (BMD) in addition to androgen deprivation therapy was examined using a murine model. Materials and Methods: The mice were separated into the following groups: control, abiraterone, castration, and castration+abiraterone. The percentage change in the ratio of bone to tissue volume (BV/TV), number of osteoblasts and osteoclasts, and the serum level of bone markers were compared on day 21. Results: The BV/TV ratio of the abiraterone, castration, and castration+abiraterone groups was lower than that of the control group. However, the change in the BV/TV ratio in the castration+abiraterone group was not significantly different from that in the castration group. There was no significant difference in the serum TRAP5b level and the number of osteoclasts and osteoblasts between the castration+abiraterone and the castration groups. Conclusion: The addition of abiraterone to castration did not affect BMD in the murine model.
- Androgen deprivation therapy
- bone mineral density
- osteoblasts
- micro-computed tomography
- bone microenvironment
Footnotes
Authors' Contributions
Conceptualization: Shiori Nakajima and Takamitsu Inoue; Data Curation: Shiori Nakajima and Takamitsu Inoue; Formal Analysis: Shiori Nakajima and Takamitsu Inoue; Funding Acquisition: Takamitsu Inoue and Tomonori Habuchi; Investigation: Shiori Nakajima, Mingguo Huang, Koichiro Takayama, Soki Kashima, and Takamitsu Inoue; Methodology: Shiori Nakajima, Koichiro Takayama, Soki Kashima, and Takamitsu Inoue; Project Administration: Shiori Nakajima, Takamitsu Inoue, Shintaro Narita, and Tomonori Habuchi; Software: Shiori Nakajima, Ryohei Yamamoto, Taketoshi Nara, and Takamitsu Inoue; Supervision: Shintaro Narita, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, and Tomonori Habuchi; Visualization: Shiori Nakajima, Atsushi Koizumi, and Takamitsu Inoue; Writing – Original Draft Preparation: Shiori Nakajima and Takamitsu Inoue; Writing – Review & Editing: Takamitsu Inoue, Shintaro Narita, and Tomonori Habuchi; All Authors have read and approved the final version of the manuscript.
This article is freely accessible online.
Funding
This work was supported by Grant Numbers 15K10617 and 16H02679 from the Japanese Society for the Promotion of Science.
Conflicts of Interest
The Authors declare that there are no conflicts of interest regarding this study.
- Received August 21, 2020.
- Revision received September 10, 2020.
- Accepted September 14, 2020.
- Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved