Research ArticleExperimental Studies

A Role for Angiogenesis in Canine Cutaneous Histiocytoma Regression: Insights into an Old Clinical Enigma

DIANA COSTA, RITA FERREIRA, JUSTINA PRADA, FELISBINA LUISA QUEIROGA, PAULA RODRIGUES, FILIPE SILVA and ISABEL PIRES
In Vivo November 2020, 34 (6) 3279-3284; DOI: https://doi.org/10.21873/invivo.12165

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  • Figure 1.
    Figure 1.

    VEGF-A expression. A) Absence of VEGF-A immunoreactivity in a group I canine cutaneous histiocytoma; B) VEGF-A positive cells with a diffuse and strong labelling in a group IV canine cutaneous histiocytoma. C) VEGFR-2 positive cells with a diffuse and strong labelling in a group I canine cutaneous histiocytoma with a diffuse and strong labelling. D) CD31 staining of endothelial cells in a group IV canine cutaneous histiocytoma.

  • Figure 2.
    Figure 2.

    Microvascularization density in the four histological groups considered (Group I: scarce and peripheral lymphocytic infiltrate; group II: moderate and peripheral lymphocytic infiltrate; group III: abundant infiltrate at the periphery and in the center; group IV: diffuse lymphocytic infiltrate) (*p<0.05; ***p<0.001).

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A Role for Angiogenesis in Canine Cutaneous Histiocytoma Regression: Insights into an Old Clinical Enigma
DIANA COSTA, RITA FERREIRA, JUSTINA PRADA, FELISBINA LUISA QUEIROGA, PAULA RODRIGUES, FILIPE SILVA, ISABEL PIRES
In Vivo Nov 2020, 34 (6) 3279-3284; DOI: 10.21873/invivo.12165
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