Research ArticleClinical Studies

Tomato Juice Consumption Could Improve Breast Skin Adverse Effects of Radiotherapy in Breast Cancer Patients

YASUYO FUKUSHI, YASUSHI MARIYA, KYOGO YAMADA, KAZUE YOSHIDA, ASAMI SASA, HITOSHI SAITO, AYUMI HIRAI, SHIGENORI SUZUKI, KOICHI AIZAWA, HIROYUKI SUGANUMA and CHIEKO ITAKI
In Vivo September 2020, 34 (5) 3013-3021; DOI: https://doi.org/10.21873/invivo.12133

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    Serial change in total carotenoid concentration. After starting tomato juice consumption from the End timepoint to 6M, concentration of total carotenoids increased. However, there was no significant difference in the values. The total carotenoid concentration data were compared by Kruskal-Wallis test. Mann-Whitney U-test was used as post hoc analysis to find significant differences, and p-values obtained were corrected by the Shaffer method. Columns and bars show average and standard deviation, respectively.

  • Figure 2.
    Figure 2.

    Serial change in lycopene concentration. After starting tomato juice consumption from End to 6M, concentration of lycopene significantly increased. The lycopene concentration data were compared by the Kruskal-Wallis test. Mann-Whitney U-test was used as post hoc analysis to find significant differences, and p-values obtained were corrected by the Shaffer method. Column and bar show average and standard deviation, respectively. a: Significantly different from Baseline (p<0.01). b: Significantly different from End (p<0.01).

  • Figure 3.
    Figure 3.

    Serial changes in difference of skin surface temperature between ipsilateral and contralateral breasts (dTemp). The values of dTemp in 3w, 4w, End, 3M and 6M were significantly higher than that in the Baseline by Mann-Whitney U-test (p<0.05). Closed circle and bar show average and standard deviation, respectively.

  • Figure 4.
    Figure 4.

    Serial changes in difference of skin moisture between ipsilateral and contralateral breasts (dMoist). The values of dMoist in all measured points except Baseline were significantly higher than that in the Baseline by t-test (p<0.05). Closed circle and bar show average and standard deviation, respectively.

  • Figure 5.
    Figure 5.

    Evaluation of late adverse events of irradiated skin by the scoring system of European Organization for Research and Treatment of Cancer Global Cosmetic (EORTC). Most patients were judged as Good or Excellent in 6M and 12M, although better in the latter.

  • Figure 6.
    Figure 6.

    Serial changes in urinary 8-OHdG levels. There were no significant differences in the values. Column and bar show average and standard deviation, respectively.

  • Figure 7.
    Figure 7.

    Relationship between concentration of lycopene and urinary 8-OHdG level in the End timepoint (n=17). The correlation coefficient was −0.73, indicating a negative correlation by Spearman's rank correlation coefficient (p<0.01).

  • Figure 8.
    Figure 8.

    Relationship between concentration of lycopene and urinary 8-OHdG level in the 3M timepoint (n=22). The correlation coefficient was −0.54, indicating a negative correlation by Pearson's correlation coefficient (p<0.01).

Tables

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Tomato Juice Consumption Could Improve Breast Skin Adverse Effects of Radiotherapy in Breast Cancer Patients
YASUYO FUKUSHI, YASUSHI MARIYA, KYOGO YAMADA, KAZUE YOSHIDA, ASAMI SASA, HITOSHI SAITO, AYUMI HIRAI, SHIGENORI SUZUKI, KOICHI AIZAWA, HIROYUKI SUGANUMA, CHIEKO ITAKI
In Vivo Sep 2020, 34 (5) 3013-3021; DOI: 10.21873/invivo.12133
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