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Research ArticleClinical Studies

Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer

MASATOSHI NAKAMURA, KAYOKO OHNISHI, HITOSHI ISHIKAWA, KENSUKE NAKAZAWA, TOSHIHIRO SHIOZAWA, TOSHIYUKI OKUMURA, IKUO SEKINE, YUKIO SATO, NOBUYUKI HIZAWA and HIDEYUKI SAKURAI
In Vivo July 2020, 34 (4) 1883-1892; DOI: https://doi.org/10.21873/invivo.11984
MASATOSHI NAKAMURA
1Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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KAYOKO OHNISHI
1Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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  • For correspondence: ohnishi{at}pmrc.tsukuba.ac.jp
HITOSHI ISHIKAWA
1Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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KENSUKE NAKAZAWA
2Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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TOSHIHIRO SHIOZAWA
2Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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TOSHIYUKI OKUMURA
1Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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IKUO SEKINE
3Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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YUKIO SATO
4Department of Thoracic Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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NOBUYUKI HIZAWA
2Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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HIDEYUKI SAKURAI
1Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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    Figure 1.

    Overall, progression-free, and distant metastasis-free survival curves for the patients in this study. Straight, dashed, and dotted lines indicate overall, progression-free, and distant metastasis-free survival, respectively.

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    Figure 2.

    Regional control and local progression-free rates. Straight and dotted lines indicate regional control and local progression-free rates, respectively.

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    Figure 3.

    Survival curves according to regional and local control. (a) Overall survival of the patients with regional control (straight line) vs. recurrence (dotted line). The 3-year rates in the control and recurrence groups were 70.3% and 53.9%, respectively (p=0.116). (b) Progression-free survival of the patients with regional control (straight line) vs. recurrence (dotted line). The 3-year rates in the control and recurrence groups were 64.6% and 15.4%, respectively (p<0.001). (c) Overall survival of the patients with local control (straight line) vs. recurrence (dotted line). The 3-year rates in the control and recurrence groups were 69.8% and 42.9%, respectively (p=0.047). (d) Progression-free survival of the patients with local control (straight line) vs. recurrence (dotted line). The 3-year rates in the control and recurrence groups were 53.6% and 14.3%, respectively (p=0.013).

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    Figure 4.

    Regional control according to treatment method. (a) Chemoradiotherapy (straight line) vs. radiotherapy alone (dotted line). (b) Proton beam therapy (straight line) vs. photon beam radiotherapy (dotted line).

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Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer
MASATOSHI NAKAMURA, KAYOKO OHNISHI, HITOSHI ISHIKAWA, KENSUKE NAKAZAWA, TOSHIHIRO SHIOZAWA, TOSHIYUKI OKUMURA, IKUO SEKINE, YUKIO SATO, NOBUYUKI HIZAWA, HIDEYUKI SAKURAI
In Vivo Jul 2020, 34 (4) 1883-1892; DOI: 10.21873/invivo.11984

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Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer
MASATOSHI NAKAMURA, KAYOKO OHNISHI, HITOSHI ISHIKAWA, KENSUKE NAKAZAWA, TOSHIHIRO SHIOZAWA, TOSHIYUKI OKUMURA, IKUO SEKINE, YUKIO SATO, NOBUYUKI HIZAWA, HIDEYUKI SAKURAI
In Vivo Jul 2020, 34 (4) 1883-1892; DOI: 10.21873/invivo.11984
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Keywords

  • radiotherapy
  • lymph node metastasis
  • oligo-recurrence
  • Non-small cell lung cancer
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