Association of an Overhydrated State With the Liver Fibrosis and Prognosis of Cirrhotic Patients

KYOHEI KISHINO; HIRAYUKI ENOMOTO; YOSHIHIRO SHIMONO; EI-ICHIRO MORIWAKI; HIROKI NISHIKAWA; TAKASHI NISHIMURA; YOSHINORI IWATA; HIROKO IIJIMA; SHUHEI NISHIGUCHI

doi:10.21873/invivo.11912

Abstract

Background/Aim: A bioimpedance analysis (BIA) can indicate an overhydrated state as the extracellular water/total body water (ECW/TBW) value. This study aimed to assess the clinical significance of this value in patients with chronic liver diseases (CLDs). Patients and Methods: A total of 552 CLD patients who received a liver biopsy and underwent anthropometric assessment and BIA-based body composition analysis were enrolled. The association of the ECW/TBW value with the liver fibrosis and nutritional status was assessed. The relationship between the ECW/TBW value and the prognosis of cirrhotic patients (N=209) was also evaluated. Results: The ECW/TBW value increased as liver fibrosis progressed and was also related to decreased muscle mass/sarcopenia. The presence of overhydration was associated with a poor prognosis of cirrhotic patients. Conclusion: An increased ECW/TBW value was associated with progressive liver fibrosis and malnutrition and related to the prognosis of cirrhotic patients.

Footnotes

Authors' Contributions
KK: data collection and analysis; HE: study design, data analysis and the manuscript writing. YS: data collection and analysis. EM, NH, TN, YI and HI: data collection; SN: data collection and supervising the study. All of the Authors read and edited the manuscript and approved the final version of the manuscript.
This article is freely accessible online.
Conflicts of Interest
The Authors declare no conflicts of interest related to this study.
Funding
This work was partly granted by Hyogo Innovative Challenge, Hyogo College of Medicine, Japan.