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Case ReportClinical Studies

Clostridial Infection After Open Fractures of the Lower Extremity – Report of Two Cases and Discussion of Pathomechanism and Treatment

MATHIAS TREMP, CARLO M. ORANGES, MARTIN MAJEWSKI, DIRK J. SCHAEFER, DANIEL F. KALBERMATTEN, CONSTANTINE BLOCH-INFANGER and PETER E. OCHSNER
In Vivo January 2020, 34 (1) 291-298; DOI: https://doi.org/10.21873/invivo.11773
MATHIAS TREMP
1Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, Basel University Hospital, University of Basel, Basel, Switzerland
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  • For correspondence: Mathias.Tremp{at}usb.ch
CARLO M. ORANGES
1Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, Basel University Hospital, University of Basel, Basel, Switzerland
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MARTIN MAJEWSKI
2Department of Orthopedic Surgery, Basel University Hospital, University of Basel, Basel, Switzerland
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DIRK J. SCHAEFER
1Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, Basel University Hospital, University of Basel, Basel, Switzerland
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DANIEL F. KALBERMATTEN
1Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, Basel University Hospital, University of Basel, Basel, Switzerland
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CONSTANTINE BLOCH-INFANGER
3Division of Infectious Diseases & Hospital Epidemiology, Basel University Hospital, University of Basel, Basel, Switzerland
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PETER E. OCHSNER
2Department of Orthopedic Surgery, Basel University Hospital, University of Basel, Basel, Switzerland
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    Figure 1.

    Case 1. A, A’: Closed dislocation fracture. B: Immediate lateral osteosynthesis after reposition. C and D: Within 3 months, inner demarcation of the cancellous bone of the tibial pilon.

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    Figure 2.

    Case 1. A: Medial revision presents a demarcation of the central tibial pilon. B: Resected parts of the pilon and the fibula. C: Undecalcified longitudinal section of the pilon, coloured with toluidine blue. An intact joint surface and a demarcated irregular cancellous bone surface are visible. D: Soft tissues of the area under high magnification show chronic infection with plasma cells and lymphocytes (10× magnification).

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    Figure 3.

    Case 1. A: Bone loss of the pilon of about 6 cm in length. B: Appearance at the end of callus distraction. C, C’: At 45 weeks later, the external fixation was removed and an orthosis applied. D: Thirteen years later subtalar arthrodesis combined with correction osteotomy of the distal tibia to overcome equinus position.

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    Figure 4.

    Case 2. A: Grade 2 open dislocation fracture helped with primary debridement and external fixation. B and C: Internal fixation 4 days later. D: Magnetic resonance imaging after 5 months with arrowheads showing strong evidence of sequestrae in the tibial pilon.

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    Figure 5.

    Case 2. Soft-tissue closure after 6 weeks. Appearance before (A and B) and after (C and D) the operation. The gracilis muscle was tunnelled medially to laterally.

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    Figure 6.

    Case 2. A, A’: Preoperative computed tomographic-scan through the tibial pilon area presenting a demarcation of the cancellous bone, which then was resected. B: Ankle fusion with external fixation. C and D: Fixation was removed 22 weeks later, when the fusion was solid enough.

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January-February 2020
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Clostridial Infection After Open Fractures of the Lower Extremity – Report of Two Cases and Discussion of Pathomechanism and Treatment
MATHIAS TREMP, CARLO M. ORANGES, MARTIN MAJEWSKI, DIRK J. SCHAEFER, DANIEL F. KALBERMATTEN, CONSTANTINE BLOCH-INFANGER, PETER E. OCHSNER
In Vivo Jan 2020, 34 (1) 291-298; DOI: 10.21873/invivo.11773

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Clostridial Infection After Open Fractures of the Lower Extremity – Report of Two Cases and Discussion of Pathomechanism and Treatment
MATHIAS TREMP, CARLO M. ORANGES, MARTIN MAJEWSKI, DIRK J. SCHAEFER, DANIEL F. KALBERMATTEN, CONSTANTINE BLOCH-INFANGER, PETER E. OCHSNER
In Vivo Jan 2020, 34 (1) 291-298; DOI: 10.21873/invivo.11773
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Keywords

  • infection
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