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Research ArticleExperimental Studies

Serum Level of microRNA-375-3p Is Not a Reliable Biomarker of Teratoma

GAZANFER BELGE, FRANCESCA GROBELNY, CORD MATTHIES, ARLO RADTKE and KLAUS-PETER DIECKMANN
In Vivo January 2020, 34 (1) 163-168; DOI: https://doi.org/10.21873/invivo.11757
GAZANFER BELGE
1Faculty of Biology and Chemistry, University of Bremen, Bremen, Germany
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  • For correspondence: belge{at}uni-bremen.de
FRANCESCA GROBELNY
1Faculty of Biology and Chemistry, University of Bremen, Bremen, Germany
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CORD MATTHIES
2Department of Urology, Bundeswehrkrankenhaus Hamburg, Hamburg, Germany
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ARLO RADTKE
1Faculty of Biology and Chemistry, University of Bremen, Bremen, Germany
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KLAUS-PETER DIECKMANN
3Department of Urology, Asklepios Klinik Altona, Hamburg, Germany
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    Figure 1.

    Boxplots of the relative miR-375-3p serum expression. Expression in serum of n=12 patients with non-malignant testicular disease (control), n=12 patients with testicular germ cell tumours (GCT) other than teratoma, and n=21 patients with teratoma was compared. The y-axis is plotted in a logarithmic scale.

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    Figure 2.

    Boxplots of the miR-375-3p serum expression in teratoma patients with different clinical stages (CS). Expression was compared between n=16 patients with CS1, n=3 patients with CS2, and n=2 CS3 patients. The y-axis is plotted in a logarithmic scale.

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    Figure 3.

    ROC curve representing the ability of serum miR-375-3p to discriminate between teratoma (n=21) and other conditions (n=24). The AUC is 0.524.

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Vol. 34, Issue 1
January-February 2020
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Serum Level of microRNA-375-3p Is Not a Reliable Biomarker of Teratoma
GAZANFER BELGE, FRANCESCA GROBELNY, CORD MATTHIES, ARLO RADTKE, KLAUS-PETER DIECKMANN
In Vivo Jan 2020, 34 (1) 163-168; DOI: 10.21873/invivo.11757

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Serum Level of microRNA-375-3p Is Not a Reliable Biomarker of Teratoma
GAZANFER BELGE, FRANCESCA GROBELNY, CORD MATTHIES, ARLO RADTKE, KLAUS-PETER DIECKMANN
In Vivo Jan 2020, 34 (1) 163-168; DOI: 10.21873/invivo.11757
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Keywords

  • microRNA
  • miR-375-3p
  • teratoma
  • testicular germ cell tumour
  • serum
  • biomarkers
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