Bisphenol A: A Concise Review of Literature and a Discussion of Health and Regulatory Implications

Abstract

Background/Aim: Bisphenol A (BPA) is a ubiquitous substance found in a wide array of consumer products and healthcare consumables, and at low doses in drinking water. Currently, in the UK, it is classed as a low-risk substance with little potential for harm. It has been known to have effects on oestrogen receptors. The implications of this for public safety is currently subject to debate. Materials and Methods: In this study, we review recent literature regarding the effects and safety of BPA, and discuss the potential implications, in particular from the perspective of human breast oncogenesis. Results and Conclusion: Recent evidence suggests that low-doses of endocrine disruptors, such as BPA, could have profound effects in breast development and cancer risk. Recent studies in murine models suggest that BPA could contribute to breast oncogenesis via several pathways. The position of regulators should shift accordingly to safeguard the public interest.