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Research ArticleClinical Studies

The Effect of Lipopolysaccharide-containing Moisturizing Cream on Skin Care in Patients With Mild Atopic Dermatitis

KOZO NAKAI, YASUO KUBOTA, GEN-ICHIRO SOMA and CHIE KOHCHI
In Vivo January 2019, 33 (1) 109-114; DOI: https://doi.org/10.21873/invivo.11446
KOZO NAKAI
1Department of Dermatology, School of Medicine, Kagawa University, Kita-gun, Japan
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YASUO KUBOTA
1Department of Dermatology, School of Medicine, Kagawa University, Kita-gun, Japan
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GEN-ICHIRO SOMA
2Control of Innate Immunity, Technology Research Association, Takamatsu, Japan
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CHIE KOHCHI
3Macrophi Inc., Takamatsu, Japan
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  • For correspondence: kohchi@macrophi.co.jp
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Abstract

Background/Aim: Recently, the prevalence of atopic dermatitis (AD) has increased in developed countries. This study aimed to examine the usefulness of a moisturizing cream containing lipopolysaccharide derived from Pantoea agglomerans (LPSp) in patients with mild AD. Patients and Methods: A moisturizing cream containing LPSp or its placebo was randomly assigned and continuously used for 4 weeks in patients with mild AD. AD severity was evaluated in a double-blind manner by a dermatologist using the Eczema Area and Severity Index (EASI) score and by the patients' self-evaluation of itching and skin condition using a visual analog scale (VAS). Results: Although there was no difference in the EASI score between the two groups, the VAS scores showed significantly greater symptom alleviation in the LPSp group than in the placebo group. Conclusion: A moisturizing cream containing LPSp may be effective for routine skin care and could help alleviate symptoms of mild AD.

  • Skin
  • itching
  • LPS
  • innate immunity
  • Received September 27, 2018.
  • Revision received October 19, 2018.
  • Accepted October 23, 2018.
  • Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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In Vivo: 33 (1)
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Vol. 33, Issue 1
January-February 2019
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The Effect of Lipopolysaccharide-containing Moisturizing Cream on Skin Care in Patients With Mild Atopic Dermatitis
KOZO NAKAI, YASUO KUBOTA, GEN-ICHIRO SOMA, CHIE KOHCHI
In Vivo Jan 2019, 33 (1) 109-114; DOI: 10.21873/invivo.11446

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The Effect of Lipopolysaccharide-containing Moisturizing Cream on Skin Care in Patients With Mild Atopic Dermatitis
KOZO NAKAI, YASUO KUBOTA, GEN-ICHIRO SOMA, CHIE KOHCHI
In Vivo Jan 2019, 33 (1) 109-114; DOI: 10.21873/invivo.11446
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Keywords

  • Skin
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