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Research ArticleClinical Studies

Pathological Complete Response by S-1 Chemotherapy in Advanced Gastric Cancer

TSUTOMU NAMIKAWA, NOBUKO ISHIDA, SACHI TSUDA, KAZUNE FUJISAWA, ERI MUNEKAGE, JUN IWABU, MASAYA MUNEKAGE, SUNAO UEMURA, SHIGEHIRO TSUJII, HIROMICHI MAEDA, HIROYUKI KITAGAWA, MICHIYA KOBAYASHI and KAZUHIRO HANAZAKI
In Vivo September 2018, 32 (5) 1211-1216; DOI: https://doi.org/10.21873/invivo.11366
TSUTOMU NAMIKAWA
1Department of Surgery, Kochi Medical School, Kochi, Japan
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  • For correspondence: tsutomun{at}kochi-u.ac.jp
NOBUKO ISHIDA
1Department of Surgery, Kochi Medical School, Kochi, Japan
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SACHI TSUDA
1Department of Surgery, Kochi Medical School, Kochi, Japan
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KAZUNE FUJISAWA
1Department of Surgery, Kochi Medical School, Kochi, Japan
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ERI MUNEKAGE
1Department of Surgery, Kochi Medical School, Kochi, Japan
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JUN IWABU
1Department of Surgery, Kochi Medical School, Kochi, Japan
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MASAYA MUNEKAGE
1Department of Surgery, Kochi Medical School, Kochi, Japan
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SUNAO UEMURA
1Department of Surgery, Kochi Medical School, Kochi, Japan
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SHIGEHIRO TSUJII
1Department of Surgery, Kochi Medical School, Kochi, Japan
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HIROMICHI MAEDA
2Cancer Treatment Center, Kochi Medical School Hospital, Kochi, Japan
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HIROYUKI KITAGAWA
1Department of Surgery, Kochi Medical School, Kochi, Japan
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MICHIYA KOBAYASHI
2Cancer Treatment Center, Kochi Medical School Hospital, Kochi, Japan
3Department of Human Health and Medical Sciences, Kochi Medical School, Kochi, Japan
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KAZUHIRO HANAZAKI
1Department of Surgery, Kochi Medical School, Kochi, Japan
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    Figure 1.

    Initial esophagogastroduodenoscopy and computed tomography. Esophagogastroduodenoscopy showed an ulcerated lesion with central, irregular, depressed tumor in the lesser curvature side of the upper third of the stomach (A). Abdominal enhanced-computed tomography showed wall thickening with homogenous enhancement in the upper part of the stomach (arrow) and enlarged lymph nodes in the perigastric area (B).

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    Figure 2.

    Histological findings of tumor biopsy specimen. The histological results indicated a moderately differentiated adenocarcinoma.

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    Figure 3.

    Esophagogastroduodenoscopy and computed tomography after systemic chemotherapy. Esophagogastroduodenoscopy showed a slightly elevated lesion with indistinct margins in the area of the original tumor (A). Abdominal enhanced-computed tomography showed remarkably reduced gastric wall thickening and a remarkable reduction in lymph node swelling (B).

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    Figure 4.

    Macroscopic appearance of the surgically resected specimen. Gross examination of the resected specimen showed a superficial, flat, slightly reddened lesion in the mucosa measuring 1.5×1.5 cm (arrow).

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    Figure 5.

    Histological findings of the surgically resected specimen. Histological analysis revealed an atrophy and fibrosis of the gastric mucosa in the lesion area, accompanied by inflammatory cell infiltration, and there was no clear infiltration of cancer cells at any site.

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September-October 2018
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Pathological Complete Response by S-1 Chemotherapy in Advanced Gastric Cancer
TSUTOMU NAMIKAWA, NOBUKO ISHIDA, SACHI TSUDA, KAZUNE FUJISAWA, ERI MUNEKAGE, JUN IWABU, MASAYA MUNEKAGE, SUNAO UEMURA, SHIGEHIRO TSUJII, HIROMICHI MAEDA, HIROYUKI KITAGAWA, MICHIYA KOBAYASHI, KAZUHIRO HANAZAKI
In Vivo Sep 2018, 32 (5) 1211-1216; DOI: 10.21873/invivo.11366

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Pathological Complete Response by S-1 Chemotherapy in Advanced Gastric Cancer
TSUTOMU NAMIKAWA, NOBUKO ISHIDA, SACHI TSUDA, KAZUNE FUJISAWA, ERI MUNEKAGE, JUN IWABU, MASAYA MUNEKAGE, SUNAO UEMURA, SHIGEHIRO TSUJII, HIROMICHI MAEDA, HIROYUKI KITAGAWA, MICHIYA KOBAYASHI, KAZUHIRO HANAZAKI
In Vivo Sep 2018, 32 (5) 1211-1216; DOI: 10.21873/invivo.11366
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Keywords

  • Gastric cancer
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  • Chemotherapy
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