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Research ArticleClinical Studies

T790M Correlates with Longer Progression-free Survival in Non-small Cell Lung Carcinomas Harboring EGFR Mutations

YOSHIHITO KOGURE, FUMIE SHIGEMATSU, MASAHIDE OKI and HIDEO SAKA
In Vivo September 2018, 32 (5) 1199-1204; DOI: https://doi.org/10.21873/invivo.11364
YOSHIHITO KOGURE
Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
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  • For correspondence: yo-kogure{at}umin.ac.jp
FUMIE SHIGEMATSU
Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
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MASAHIDE OKI
Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
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HIDEO SAKA
Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
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    Figure 1.

    Flow chart of the study procedure. PD: Progressive disease; EGFR-TKI: epidermal growth factor receptor-tyrosine kinase inhibitor.

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    Figure 2.

    Number of progressive lesions in PD cases after initial EGFR-TKI therapy. CSF: Cerebrospinal fluid; PD: progressive disease; EGFR: epidermal growth factor receptor; TKI: tyrosine kinase inhibitor. “Others” include the kidney, spleen, skin, ascites, and thyroid gland.

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    Figure 3.

    Progression-free survival after initial EGFR-TKI therapy, based on the T790M status.

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    Figure 4.

    Association between rebiopsy site and T790M status.

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In Vivo
Vol. 32, Issue 5
September-October 2018
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T790M Correlates with Longer Progression-free Survival in Non-small Cell Lung Carcinomas Harboring EGFR Mutations
YOSHIHITO KOGURE, FUMIE SHIGEMATSU, MASAHIDE OKI, HIDEO SAKA
In Vivo Sep 2018, 32 (5) 1199-1204; DOI: 10.21873/invivo.11364

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T790M Correlates with Longer Progression-free Survival in Non-small Cell Lung Carcinomas Harboring EGFR Mutations
YOSHIHITO KOGURE, FUMIE SHIGEMATSU, MASAHIDE OKI, HIDEO SAKA
In Vivo Sep 2018, 32 (5) 1199-1204; DOI: 10.21873/invivo.11364
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Keywords

  • EGFR mutation
  • T790M
  • Non-small cell lung carcinoma
  • rebiopsy
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