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Research ArticleClinical Studies

Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study

KAKUHIRO YAMAGUCHI, TAKESHI MASUDA, KAZUNORI FUJITAKA, KEI MIWATA, SHINJIRO SAKAMOTO, YASUSHI HORIMASU, KOSUKE HAMAI, SHINTARO MIYAMOTO, TAKU NAKASHIMA, YOHEI OKAMOTO, HIROSHI IWAMOTO, NOBUHISA ISHIKAWA, YOSHIHIRO MIYATA, MORIHITO OKADA, HIRONOBU HAMADA and NOBORU HATTORI
In Vivo September 2018, 32 (5) 1155-1160; DOI: https://doi.org/10.21873/invivo.11358
KAKUHIRO YAMAGUCHI
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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TAKESHI MASUDA
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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KAZUNORI FUJITAKA
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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  • For correspondence: fujikazu{at}hiroshima-u.ac.jp
KEI MIWATA
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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SHINJIRO SAKAMOTO
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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YASUSHI HORIMASU
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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KOSUKE HAMAI
2Department of Respiratory Medicine, Hiroshima Prefectural Hospital, Hiroshima, Japan
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SHINTARO MIYAMOTO
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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TAKU NAKASHIMA
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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YOHEI OKAMOTO
3Nakanohigashi Clinic, Hiroshima, Japan
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HIROSHI IWAMOTO
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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NOBUHISA ISHIKAWA
2Department of Respiratory Medicine, Hiroshima Prefectural Hospital, Hiroshima, Japan
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YOSHIHIRO MIYATA
4Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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MORIHITO OKADA
4Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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HIRONOBU HAMADA
5Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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NOBORU HATTORI
1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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    Figure 1.

    Kaplan–Meier analysis showing progression-free survival (PFS) for patients with non-squamous non-small-cell lung cancer treated with bevacizumab in combination with docetaxel or pemetrexed. The median PFS (mPFS) was 5.0 months [95% confidence interval (CI)=3.2-8.8 months] (A), and there was no significant difference in PFS between patients treated in the second-line (mPFS=6.4 months, 95% CI=1.4-16.1 months) and third-line setting or later (mPFS=4.9 months, 95% CI=3.0-7.0 months) (B).

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    Figure 2.

    Kaplan–Meier analysis showing overall survival for patients with non-squamous non-small-cell lung cancer treated with bevacizumab in combination with docetaxel or pemetrexed. The median survival duration was 15.8 months (95% confidence interval=10.5-19.6 months).

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September-October 2018
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Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study
KAKUHIRO YAMAGUCHI, TAKESHI MASUDA, KAZUNORI FUJITAKA, KEI MIWATA, SHINJIRO SAKAMOTO, YASUSHI HORIMASU, KOSUKE HAMAI, SHINTARO MIYAMOTO, TAKU NAKASHIMA, YOHEI OKAMOTO, HIROSHI IWAMOTO, NOBUHISA ISHIKAWA, YOSHIHIRO MIYATA, MORIHITO OKADA, HIRONOBU HAMADA, NOBORU HATTORI
In Vivo Sep 2018, 32 (5) 1155-1160; DOI: 10.21873/invivo.11358

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Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study
KAKUHIRO YAMAGUCHI, TAKESHI MASUDA, KAZUNORI FUJITAKA, KEI MIWATA, SHINJIRO SAKAMOTO, YASUSHI HORIMASU, KOSUKE HAMAI, SHINTARO MIYAMOTO, TAKU NAKASHIMA, YOHEI OKAMOTO, HIROSHI IWAMOTO, NOBUHISA ISHIKAWA, YOSHIHIRO MIYATA, MORIHITO OKADA, HIRONOBU HAMADA, NOBORU HATTORI
In Vivo Sep 2018, 32 (5) 1155-1160; DOI: 10.21873/invivo.11358
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