Article Figures & Data
Figures
- Figure 1.
Adjuvant-induced arthritis (AA) generates paw edema (A), mechanical hyperalgesia (B), and weight loss (C). Data represent the mean±SD, (n=3). ● AA, ○ Control. *Statistically significant difference compared with control rats at p<0.05.
- Figure 2.
Representative plot of velocity versus morphine concentration for the 3-glucuronidation of morphine in rat liver microsomes. The solid lines are computer-generated curves for best fit. Data represent the mean±SD. ● Adjuvant-induced arthritis (AA), ○ Control.
- Figure 3.
Changes in relative protein levels of ATP-binding cassette transporters (ABC) C1 in microsomal proteins from livers of rats with adjuvant-induced arthritis (AA). Densitometric quantification of ABCC1 was performed and expression values were normalized to those of β-actin. Representative blots of two independent experiments are shown (n=3).
- Figure 4.
Binding of morphine to serum protein in rats with adjuvant-induced arthritis (AA) and controls. *Statistically significant difference compared to controls at p<0.05.
- Figure 5.
Plasma concentration time course of morphine (A) and morphine-3-glucuronide (B) in rats with adjuvant-induced arthritis (AA) after a single administration of morphine (5 mg/kg). Data represent the mean±SD (n=3).*Statistically significant differences compared to control groups at p<0.05.
- Figure 6.
Anti-nociceptive effects of morphine (Mor) in rats with arthritis induced by complete Freund's adjuvant (CFA) and vehicle-treated controls (Veh) are presented as a percentage of the maximum possible effect (MPE). ● CFA+Mor, ○ Veh+Mor, ▴ CFA, ▵ Veh (A) and The area under each effect-versus-time curve (AUC) for the tail flick test (B). AUC calculations were performed using the trapezoidal method. Data represent the mean±SD (n=5). *Statistically significant difference compared with control groups at p<0.05.
