Research ArticleClinical Studies

Elevated Serum AA/EPA Ratio as a Predictor of Skeletal Muscle Depletion in Cachexic Patients with Advanced Gastro-intestinal Cancers

MOEKO KITAGAWA, SEIJI HAJI and TERUYOSHI AMAGAI
In Vivo September 2017, 31 (5) 1003-1009;

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Figures

  • Figure 1.
    Figure 1.

    Flow chart of this study. All consecutive patients with with unresectable advanced gastro-intestinal (GI) cancer (stage IV) undergoing chemotherapy on in- or outpatient basis at our Institution. Alb: Albumin; CRP: C-reactive protein; ALA: α-linolenic acid; EPA: eicosapentaenoic acid; DHA: docosahexaenoic acid; LA: linoleic acid; GLA: γ-linolenic acid; AA: arachidonic acid; Sum of n-3 FAs: ALA+EPA+DHA; Sum of n-6 FAs: LA+GLA+AA. aLiver dysfunction: AST >40 IU/L or ALT >40 IU/L, T-Bil >1.5 mg/dl. bRenal dysfunction: serum-creatinine >1.5 mg/dl.

  • Figure 2.
    Figure 2.

    Correlation between ΔPMI (%) and CRP. The blood samples were drawn one day before surgery. ΔPMI: Psoas muscle index change rate; CRP: C-reactive protein.

  • Figure 3.
    Figure 3.

    Correlation between ΔPMI (%) and serum n-6/n-3 ratio. The blood samples were drawn one day before surgery. ΔPMI: Psoas muscle index change rate; ALA: α-linolenic acid; EPA: eicosapentaenoic acid; DHA: docosahexaenoic acid; LA: linoleic acid; GLA: γ-linolenic acid; AA: arachidonic acid; Sum of n-3 FAs: ALA+EPA+DHA; Sum of n-6 FAs: LA+GLA+AA.

Tables

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  • Table III.
  • Table IV.
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Elevated Serum AA/EPA Ratio as a Predictor of Skeletal Muscle Depletion in Cachexic Patients with Advanced Gastro-intestinal Cancers
MOEKO KITAGAWA, SEIJI HAJI, TERUYOSHI AMAGAI
In Vivo Sep 2017, 31 (5) 1003-1009;
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