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Review ArticleReviewsR

Factors Associated with Microalbuminuria Remission in Patients with Type 2 Diabetes: Importance of Early Intervention for Microalbuminuric Patients (TSUGARU STUDY)

NORIO NAKAMURA, IKUYO NARITA, TAKESHI FUJITA, REIICHI MURAKAMI, MICHIKO SHIMADA, MASAYUKI NAKAMURA, HIROSHI OSAWA, HIDEAKI YAMABE, KEN OKUMURA and for THE DIABETIC NEPHROPATHY TREATMENT STUDY GROUP
In Vivo May 2017, 31 (3) 285-290;
NORIO NAKAMURA
1Community Medicine, Hirosaki University Graduate School of Medicine, Aomori, Japan
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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  • For correspondence: nnakamur@r2.dion.ne.jp
IKUYO NARITA
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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TAKESHI FUJITA
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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REIICHI MURAKAMI
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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MICHIKO SHIMADA
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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MASAYUKI NAKAMURA
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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HIROSHI OSAWA
3Department of General Medicine, Hirosaki University Hospital, Aomori, Japan
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HIDEAKI YAMABE
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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KEN OKUMURA
2Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan
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Abstract

Aim: The aim of this study was to clarify the rates of remission and progression for microalbuminuria in patients with type 2 diabetes (T2DM); and factors associated with remission and progression of diabetic nephropathy (DN). Patients and Methods: T2DM patients with a urinary albumin excretion (UAE) rate of 30-300 mg/gCr who were attending the medical clinic in the Tsugaru region in Japan were enrolled into this prospective, observational study for 36 months (N=317). We investigated the rate of remission (UAE <30 mg/g creatinine (Cr); normal albuminuria) and the rate of progression (UAE ≥300 mg/gCr; overt proteinuria) 36 months after study registration. Results: The number of patients whose UAE levels were <30 mg/gCr (DN remission) at 36 months after registration was 64 (27.4%), and the number of patients whose UAE levels were ≥300 mg/gCr (DN progression) at 36 months after registration was 32 (13.7%). From multiple logistic regression analysis, the sole factor that contributed to remission at 36 months after registration was the UAE levels at registration (OR: 0.99; 95% CI: 0.98-1.00, p=0.003), and the factors that contributed to progression at 36 months after registration were the levels of UAE (OR: 1.01; 95% CI: 1.01-1.02, p=0.000) and systolic blood pressure (OR: 0.96; 95% CI: 0.93-1.00, p=0.033) at registration. Conclusion: Results suggest that patients with less severe microalbuminuria among microalbuminuric patients might more commonly experience DN remission and that earlier intervention is very important for promoting microalbuminuria remission in DN.

  • Diabetic nephropathy
  • microalbuminuria
  • urinary albumin excretion (UAE)
  • Received February 21, 2017.
  • Revision received March 19, 2017.
  • Accepted March 21, 2017.
  • Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Factors Associated with Microalbuminuria Remission in Patients with Type 2 Diabetes: Importance of Early Intervention for Microalbuminuric Patients (TSUGARU STUDY)
NORIO NAKAMURA, IKUYO NARITA, TAKESHI FUJITA, REIICHI MURAKAMI, MICHIKO SHIMADA, MASAYUKI NAKAMURA, HIROSHI OSAWA, HIDEAKI YAMABE, KEN OKUMURA, for THE DIABETIC NEPHROPATHY TREATMENT STUDY GROUP
In Vivo May 2017, 31 (3) 285-290;

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Factors Associated with Microalbuminuria Remission in Patients with Type 2 Diabetes: Importance of Early Intervention for Microalbuminuric Patients (TSUGARU STUDY)
NORIO NAKAMURA, IKUYO NARITA, TAKESHI FUJITA, REIICHI MURAKAMI, MICHIKO SHIMADA, MASAYUKI NAKAMURA, HIROSHI OSAWA, HIDEAKI YAMABE, KEN OKUMURA, for THE DIABETIC NEPHROPATHY TREATMENT STUDY GROUP
In Vivo May 2017, 31 (3) 285-290;
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Keywords

  • Diabetic nephropathy
  • microalbuminuria
  • urinary albumin excretion (UAE)
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