Research ArticleExperimental Studies

Apoptosis-inducing Effect of a Palladium(II) Complex-[PdCl(terpy)](sac).2H2O] on Ehrlich Ascites Carcinoma (EAC) in Mice

ELIF I. IKITIMUR-ARMUTAK, ENGIN ULUKAYA, EBRU GUREL-GUREVIN, ILHAN YAYLIM, BANU ISBILEN-BASOK, GULBIN SENNAZLI, GULAY YUZBASIOGLU-OZTURK, KIVILCIM SONMEZ, FARUK CELIK, OZLEM KUCUKHUSEYIN, GURBET KORKMAZ, VEYSEL T. YILMAZ and SAKIR UMIT ZEYBEK
In Vivo July 2016, 30 (4) 457-464;

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    Comparison of immunohistochemistry and TUNEL assay data. A: Proliferating cell nuclear antigen (PCNA), B: P53, C: Bax, D: active caspase 3 (AC3), E: TUNEL, F: Bcl-2. *p<0.05, ***p<0.001, versus control group. +p<0.05, +++p<0.001, versus cisplatin group.

  • Figure 2.
    Figure 2.

    Expression of proliferating cell nuclear antigen (PCNA), active caspase-3 (AC3), P53, Bax, and Bcl-2 in complex-3 mg/kg treated (A, C, E, G, I) and control (B, D, F, H, J) groups. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) in complex-3 mg/kg treated (K) and control (L) groups (Bar=50 μm).

  • Figure 3.
    Figure 3.

    Statistical comparison of GSK-3 Beta [pS9] (A) and IRS-1 [pS312] (B) according to luminex results. *p<0.05, **p<0.01, ***p<0.001, versus control group. +p<0.05, ++p<0.01, +++p<0.001, versus cisplatin group.

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Apoptosis-inducing Effect of a Palladium(II) Complex-[PdCl(terpy)](sac).2H2O] on Ehrlich Ascites Carcinoma (EAC) in Mice
ELIF I. IKITIMUR-ARMUTAK, ENGIN ULUKAYA, EBRU GUREL-GUREVIN, ILHAN YAYLIM, BANU ISBILEN-BASOK, GULBIN SENNAZLI, GULAY YUZBASIOGLU-OZTURK, KIVILCIM SONMEZ, FARUK CELIK, OZLEM KUCUKHUSEYIN, GURBET KORKMAZ, VEYSEL T. YILMAZ, SAKIR UMIT ZEYBEK
In Vivo Jul 2016, 30 (4) 457-464;
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