Article Figures & Data
Figures
- Figure 1.
Stem cell antigen-1 (SCA-1) protein expression in lungs from ground control mice housed in animal enclosure modules (AEM) and flight (FLT) mice. Top panels show representative images after staining with fluorescein isothiocyanate-labeled antibody against SCA-1. The signal in bronchiolar epithelial cells in the spaceflight samples was strong, while the immunoreactivity for this marker was negative in AEM samples. Magnification is ×40; magnification bar is 10 mm. The bar graph shows means and standard errors for n=4 mice/group. *p<0.05 vs. AEM.
- Figure 2.
Apoptosis in the lungs from ground control mice housed in animal enclosure modules (AEM) and flight (FLT) mice. Representative examples of sections stained using the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay are shown in the top panels. TUNEL-positive cells: green; nuclei: blue. Magnification is ×40; magnification bar is 10 mm. The bar graph presents the means and standard errors for n=3-4/group. *p<0.05 vs. AEM.
- Figure 3.
Representative examples of lung sections from ground control mice housed in animal enclosure modules (AEM) and flight (FLT) mice stained with hematoxylin and eosin. No significant abnormalities were noted in lungs of FLT mice with respect to inflammation, necrosis, vascular changes, metaplasia, edema or cellular atypia. Magnification is ×20.
- Figure 4.
Local network of functionally related genes. The figure was generated using Ingenuity Pathway Analysis software (www.ingenuity.com). Only genes in the lungs from the flight (FLT) mice that differed in expression from the control mice housed in animal enclosure modules (AEM) with a significance of p<0.1 and that directly interacted with the other measured genes were included. Col5a1: Collagen, type V, alpha 1; Crebbp: CREB binding protein; Fgfr1: fibroblast growth factor receptor 1; Fgfr3: fibroblast growth factor receptor 3; Fn1: fibronectin 1; Hapln1: hyaluronan and proteoglycan link protein 1; Itga5: integrin alpha 5; Lamc1: laminin, gamma 1; Mmp2: matrix metallopeptidase 2; Mmp13: matrix metallopeptidase 13; Mmp14: matrix metallopeptidase 14; Ncam1: neural cell adhesion molecule 1; Nfatc4: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; Notch4: notch gene homolog 4; Rbl1: retinoblastoma-like 1; Selp: selectin, platelet; Smad2: MAD homolog 2; Tgfbi: transforming growth factor, beta induced; Thbs1: thrombospondin 1; Thbs2: thrombospondin 2; Timp2: tissue inhibitor of metalloproteinase 2; Vcan: versican.
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