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Review ArticleReviewR

Curcumin Suppression of Cytokine Release and Cytokine Storm. A Potential Therapy for Patients with Ebola and Other Severe Viral Infections

PETER P. SORDILLO and LAWRENCE HELSON
In Vivo January 2015, 29 (1) 1-4;
PETER P. SORDILLO
SignPath Pharma, Inc., Quakertown, PA, U.S.A.
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LAWRENCE HELSON
SignPath Pharma, Inc., Quakertown, PA, U.S.A.
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Abstract

Background: The terminal stage of Ebola and other viral diseases is often the onset of a cytokine storm, the massive overproduction of cytokines by the body's immune system. Materials and Methods: The actions of curcumin in suppressing cytokine release and cytokine storm are discussed. Results: Curcumin blocks cytokine release, most importantly the key pro-inflammatory cytokines, interleukin-1, interleukin-6 and tumor necrosis factor-α. The suppression of cytokine release by curcumin correlates with clinical improvement in experimental models of disease conditions where a cytokine storm plays a significant role in mortality. Conclusion: The use of curcumin should be investigated in patients with Ebola and cytokine storm. Intravenous formulations may allow achievement of therapeutic blood levels of curcumin

  • Curcumin
  • cytokine storm
  • Ebola
  • interleukin-1
  • interleukin-6
  • tumor necrosis factor-α
  • review

The high fatality rate in patients infected with the Ebola virus is thought to be due partly to the onset of a cytokine storm in the advanced stages of the infection (1, 2). Cytokine storm can occur after a wide variety of infectious and non-infectious stimuli. In cytokine storm, numerous cytokines, both pro-inflammatory such as interleukin-1 (IL1), IL6, tumor necrosis factor-α (TNFα), and anti-inflammatory (IL10), are released, resulting in hypotension, hemorrhage, and, ultimately, multi-organ failure. The term ‘cytokine storm’ is most associated with the 1918 H1N1 influenza pandemic and the more recent cases of bird flu H5N1 infection (3-5). In these cases, young people, with presumably healthy immune systems, died disproportionally from this disease, and aberrant activity of their immune systems is thought to be the cause. This syndrome has been also known to occur in advanced or terminal cases of severe acute respiratory syndrome (SARS) (6), Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (7), gram-negative sepsis (8), malaria (9) and numerous other infectious diseases. Cytokine storm can occur from non-infectious causes, such as acute pancreatitis (10), severe burns or trauma (11), or acute respiratory distress syndrome secondary to drug use or inhalation of toxins (12). In a recent phase I trial, injection of the monoclonal antibody TGN1412, which binds to the CD28 receptor on T-cells, resulted in severe cases of cytokine storm and multi-organ failure in the six human volunteers who received this agent. This happened despite the fact that the dose of this agent given was 500-times lower than which had been found to be safe in animals (13).

Curcumin Suppression of Cytokines

Curcumin has been shown to inhibit the release of numerous cytokines. Abe et al. showed that curcumin suppresses IL1β, IL8, TNFα, monocyte chemoattractant protein-1 (MCP1) and macrophage inflammatory protein-1α (MIP1α) release from monocytes and macrophages (14). Jain et al. showed that curcumin markedly reduced the release of IL6, IL8, TNFα and MCP1 from monocytes that had been cultured in a high glucose environment (15). These same investigators studied rats with streptozotocin-induced elevated plasma blood sugar levels and significantly elevated levels of IL6, TNFα and MCP1; these levels were markedly reduced by curcumin (15). Curcumin has been reported to block the release of IL6 in rheumatoid synovial fibroblasts (16), of IL8 in human esophageal epithelial cells (17) and alveolar epithelial cells (18), and of IL1 in bone marrow stromal cells (19), colonic epithelial cells (20) and human articular chondrocytes (21). Curcumin also prevents release of IL2 (22), IL12 (22, 23), interferon-γ (22, 23) and many other key cytokines (24-26) (Tables I and II).

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Table I.

Effect of curcumin on interleukins (IL).

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Table II.

Curcumin suppression of other key cytokines.

Cytokine Suppression by Curcumin Correlates with Clinical Improvement in Conditions Associated with Cytokine Storm

Curcumin has positive effects on numerous disease conditions in patients and in animal systems. Avasarala et al. reported on the effects of curcumin on cytokine expression and disease progression in a mouse model of virus induced acute respiratory distress syndrome. Curcumin reduced the expression of key cytokines IL6, IL10, interferon γ and MCP1, and this correlated with a marked decrease in inflammation and reduction in fibrosis (27). Yu et al. showed suppression of TNFα levels by curcumin was associated with decreased pancreatic injury in a mouse model of acute pancreatitis (28). Cheppudira et al. reported that suppression of IL8 and growth-regulated protein-α (GROα), and ultimately of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), by curcumin correlated with reduction in thermal injury in a rat model (29). Curcumin suppression of cytokines also correlates with clinical improvement in models of severe viral infection. Song et al. showed that curcumin administration reduced expression of IL1β, IL6 and TNFα and ultimately NFκB, and protected against coxsackie virus-induced severe myocardial damage in infected mice (30). Curcumin has been shown to have activity against numerous viruses, including human immunodeficiency virus-1(HIV1), HIV2, herpes simplex virus (HSV), human papillomavirus (HPV), human T-lymphotropic virus-1 (HTLV1), hepatitis B virus (HBV), HCV, and Japanese encephalitis virus (31). In addition, curcumin has been shown to have specific activity against the H1N1 virus in culture (32, 33), although cytokine levels were not measured in these two studies. Most importantly, curcumin has been shown to stimulate the suppressor of cytokine signaling (SOCS) proteins (34). These proteins have been shown to be crucial in protecting against severe cytokine storm in mice infected with influenza virus (35).

Conclusion

The activity of curcumin in suppressing multiple cytokines, and its activity in experimental models of diseases and conditions associated with cytokine storm, suggest it may be useful in the treatment of patients with Ebola and cytokine storm. Curcumin is poorly absorbed from the intestinal tract; however, intravenous formulations may allow therapeutic blood levels of curcumin to be achieved in patients diagnosed with cytokine storm. Clinical status and levels of important cytokines, such as IL1β, IL6 and TNFα, should be monitored carefully when patients are treated with curcumin.

Footnotes

  • Conflicts of Interest

    The Authors acknowledge a potential conflict of interest. Dr. Sordillo is a member of the Scientific Advisory Board of SignPath Pharma, which makes several formulations of intravenous curcumin. Dr. Helson is CEO of SignPath Pharma. The Authors believe that this article is of substantial scientific interest and should be published with acknowledgement of this potential conflict.

  • This article is freely accessible online.

  • Received October 23, 2014.
  • Revision received November 7, 2014.
  • Accepted November 13, 2014.
  • Copyright © 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved

References

  1. ↵
    1. Wauquier N,
    2. Becquart P,
    3. Padilla C,
    4. Baize S,
    5. Leroy EM
    : Human fatal Zaire Ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. PloS Negl Trop Dis 4(10) http://dx.doi.org/10.1371/journal.pntd.2010.0000837.
  2. ↵
    1. Villinger F,
    2. Rollin PE,
    3. Brar SS,
    4. Chikkala NF,
    5. Winter J,
    6. Sundstrom JB,
    7. Zaki SR,
    8. Swanepoel R,
    9. Ansari AA,
    10. Peters CJ
    : Markedly elevated levels of interferon (IFN)γ, IFNα, interleukin (IL)-2, IL10 and tumor necrosis factor-α associated with fatal Ebola virus infection. J Infect Dis 179: S188-S191, 1999.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Yuen KY,
    2. Wong SS
    : Human infection by avian influenza H5N1. Hong Kong Med J 11: 189-199, 2005.
    OpenUrlPubMed
    1. Haque A,
    2. Hober D,
    3. Kasper LH
    : Confronting potential influenza A (H5N1) pandemic with better vaccines. Emerg Infect Dis 13: 1512-1518, 2007.
    OpenUrlPubMed
  4. ↵
    1. Teijaro JR,
    2. Walsh KB,
    3. Rice S,
    4. Rosen H,
    5. Oldstone MBA
    : Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection. Proc Natl Acad Sci 111: 3799-3804, 2014.
    OpenUrlAbstract/FREE Full Text
  5. ↵
    1. Huang KJ,
    2. Siu IJ,
    3. Theron M,
    4. Wu YC,
    5. Liu CC,
    6. Lei HY
    : An interferon-gamma related cytokine storm in SARS patients. J Med Virol 75: 185-194, 2005.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Imashuku S
    : Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagochytic lymphohistiocytosis. Crit. Rev Oncol Hematol 44: 259-272, 2002.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Harrison C
    : Sepsis: Calming the cytokine storm. Nature Rev Drug Discover 9: 360-361, 2010.
    OpenUrl
  8. ↵
    1. Clark IA,
    2. Alleva LM,
    3. Budd AC,
    4. Cowden WB
    : Understanding the role of inflammatory cytokines in malaria and related diseases. Travel Med Infect Dis 6: 67-81, 2008.
    OpenUrlCrossRefPubMed
  9. ↵
    1. Makhija R,
    2. Kingsnorth AN
    : Cytokine storm in acute pancreatitis. J. Hepatobiliary Pancreat Surg 9: 401-410, 2002.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Aikawa N
    : Cytokine storm in the pathogenesis of multiple organ dysfunction syndrome associated with surgical insults. Nihon Geka Gakkei Zasshi 97: 771-777, 1996.
    OpenUrl
  11. ↵
    1. Park WY,
    2. Goodman RB,
    3. Steinberg KP,
    4. Ruzinsky JT,
    5. Rudella F,
    6. Park DR,
    7. Pugin J,
    8. Skeritt SJ,
    9. Hudson LD,
    10. Martin TR
    : Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Amer J Resp Crit Care Med 164: 1896-1903, 2001.
    OpenUrlCrossRefPubMed
  12. ↵
    1. St. Clair EW
    : The calm after the cytokine storm: Lessons from the TGN1412 trial. J Clin Invest 118: 1344-1347, 2008.
    OpenUrlCrossRefPubMed
  13. ↵
    1. Abe Y,
    2. Hashimoto S,
    3. Horie T
    : Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res 39: 41-47, 1999.
    OpenUrlCrossRefPubMed
  14. ↵
    1. Jain SK,
    2. Rains J,
    3. Croad J,
    4. Larson B,
    5. Jones K
    : Curcumin supplementation lowers TNFα, IL6, IL8, and MCP1 secretion in high glucose-treated cultured monocytes and blood levels of TNFα, IL6, MCP1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid Redox Signal 11: 241–249, 2009.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Kloesch B,
    2. Becker T,
    3. Dietersdorfer E,
    4. Kiener H,
    5. Steiner G
    : Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes. Int Immunopharmacol 15: 400-405, 2013.
    OpenUrlPubMed
  16. ↵
    1. Raflee P,
    2. Nelson VM,
    3. Manley S,
    4. Wellner M,
    5. Floer M,
    6. Binion DG,
    7. Shaker R
    : Effect of curcumin on acidic pH-induced expression of IL6 and IL8 in human esophageal epithelial cells (HET1A): Role of PKC, MAPKs, and NFκB. Amer J Physiol-Gastrointest Liver Physiol 296: G388-G398, 2009.
    OpenUrl
  17. ↵
    1. Biswas SK,
    2. McClure D,
    3. Jimenez LA,
    4. Megson IL,
    5. Rahman I
    : Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity. Antioxid Redox Signal 7: 32-41, 2005.
    OpenUrlCrossRefPubMed
  18. ↵
    1. Xu YX,
    2. Pindolia KR,
    3. Janakiraman N,
    4. Chapman RA,
    5. Gautam SC
    : Curcumin inhibits IL1α and TNFα induction of AP1 and NFκB DNA-binding activity in bone marrow stromal cells. Hematopathol Mol Hematol 11: 49-62, 1997-1998.
    OpenUrlPubMed
  19. ↵
    1. Jobin C,
    2. Bradham CA,
    3. Russo MP,
    4. Juma B,
    5. Narula AS,
    6. Brenner DA,
    7. Sartor RB
    : Curcumin blocks cytokine-mediated NFκβ activation and proinflammatory gene expression by inhibiting inhibitory factor Iκβ kinase activity. J Immunol 163: 3474-3483, 1999.
    OpenUrlAbstract/FREE Full Text
  20. ↵
    1. Henrotin Y,
    2. Clutterbuck AL,
    3. Allaway D,
    4. Lodwig EM,
    5. Harris P,
    6. Mathy-Hartert M,
    7. Shakibaei M,
    8. Mobasheri A
    : Biological actions of curcumin on articular chondrocytes. Osteoarthr Cartil 18: 141-149, 2010.
    OpenUrlCrossRefPubMed
  21. ↵
    1. Gao X,
    2. Kuo J,
    3. Jiang H,
    4. Deeb D,
    5. Liu Y,
    6. Divine G,
    7. Chapman RA,
    8. Dulchavsky SA,
    9. Gautam SC
    : Immunomodulatory activity of curcumin: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxity, and cytokine production in vitro. Biochem Pharmacol 68: 51-61, 2004.
    OpenUrlCrossRefPubMed
  22. ↵
    1. Fahey AJ,
    2. Robins RA,
    3. Constantinescu CS
    : Curcumin modulation of IFNβ and IL12 signaling and cytokine induction in human T-cells. J Cell Mol Med 11: 1129-1137, 2007.
    OpenUrlCrossRefPubMed
  23. ↵
    1. Bachmeier BE,
    2. Mohrenz IV,
    3. Mirisola V,
    4. Schleicher E,
    5. Romeo F,
    6. Hohneke C,
    7. Jochum M,
    8. Nerlich AG,
    9. Pfeffer U
    : Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis 29: 779-789, 2008.
    OpenUrlAbstract/FREE Full Text
    1. Xiaoling MU,
    2. Jing Z,
    3. Fang X,
    4. Liangdan T
    : Curcumin inhibits invasion and metastasis in the human ovarian cancer cells SKOV3 by CXCL12–CXCR4 axis. Afr J Biotechnol 9: 8230-8234, 2010.
    OpenUrl
  24. ↵
    1. Xu YX,
    2. Pindolia KR,
    3. Janakiraman N,
    4. Noth CJ,
    5. Chapman RA,
    6. Gautam SC
    : Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down regulates chemokine expression in bone marrow stromal cells. Exp Hematol 25: 413-422, 1997.
    OpenUrlPubMed
  25. ↵
    1. Avasarala S,
    2. Zhang F,
    3. Liu G,
    4. Wang R,
    5. London SD,
    6. London L
    : Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome. PLoS ONE 8(2) http://dx.doi.org/10.1371/journal.pone.2013.0057285.
  26. ↵
    1. Yu WG,
    2. Xu G,
    3. Ren GJ,
    4. Xu X,
    5. Yuan HQ,
    6. Qi XL,
    7. Tian KL
    : Preventive action of curcumin in experimental acute pancreatitis in mouse. Indian J Med Res 134: 717-724, 2011.
    OpenUrlCrossRefPubMed
  27. ↵
    1. Cheppudira B,
    2. Greer A,
    3. Mares A,
    4. Fowler M,
    5. Garza T,
    6. Petz L,
    7. Loyd D,
    8. Clifford J
    : The anti-inflammatory and analgesic activity of curcumin in a rat model of full thickness thermal injury. J Pain 14: 552, 2013.
    OpenUrl
  28. ↵
    1. Song Y,
    2. Ge W,
    3. Cai H,
    4. Zwang H
    : Curcumin protects mice from coxsackie virus B3-induced myocarditis by inhibiting the phosphatidylinositol 3 kinase/Akt/nuclear factor-κB pathway. J Cardiovasc Pharmacol Ther 18: 560-569, 2013.
    OpenUrlAbstract/FREE Full Text
  29. ↵
    1. Moghadamtousi SZ,
    2. Kadir HA,
    3. Hassandarvish P,
    4. Tajik H,
    5. Abubakar S,
    6. Zandi K
    : A review on antibacterial, antiviral, and antifungal activity of curcumin Biomed Res Int 2014 http://dx.doi.org/10.1155/2014.186864.
  30. ↵
    1. Chen DY,
    2. Shien JH,
    3. Tiley L,
    4. Chiou SS,
    5. Wang SY,
    6. Chang TJ,
    7. Lee YJ,
    8. Chan KW,
    9. Hsu WL
    : Curcumin inhibits influenza virus infection and haemagglutination activity. Food Chem 119: 1346-1351, 2010.
    OpenUrl
  31. ↵
    1. Ou JL,
    2. Mizushina Y,
    3. Wang SY,
    4. Chuang DY,
    5. Nadar M,
    6. Hsu WL
    : Structure–activity relationship analysis of curcumin analogues on anti-influenza virus activity. FEBS J 280: 5829-5840, 2013.
    OpenUrlPubMed
  32. ↵
    1. Chen CQ,
    2. Yu K,
    3. Yan QX,
    4. Xing CY,
    5. Chen Y,
    6. Yan Z,
    7. Shi YF,
    8. Zhao KW,
    9. Gao SM
    : Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases. Carcinogenesis 34: 1442-1449, 2013.
    OpenUrlAbstract/FREE Full Text
  33. ↵
    1. Kedzierski L,
    2. Linossi EM,
    3. Kolesnik TB,
    4. Day EB,
    5. Bird NL,
    6. Kile BT,
    7. Belz GT,
    8. Metcalf D,
    9. Nicola NA,
    10. Kedzierska K,
    11. Nicholson SE
    : Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathog 10(5) http://dx.doi.org/10:1371/journal.ppat.2014.1004134.
    1. Ganjali S,
    2. Sahebkar A,
    3. Mahdipour E,
    4. Jamialahmadi K,
    5. Torabi S,
    6. Akhlaghi S,
    7. Ferns G,
    8. Parizadeh SMR,
    9. Ghayour-Mobarhan M
    : Investigation of the effects of curcumin on serum cytokines in obese individuals: A randomized controlled study. Sci World J 2014 http://dx.doi.org/10.1155/2014.898361.
    1. Kobayashi T,
    2. Hashimoto S,
    3. Horie T
    : Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Biochem Pharmacol 54: 819-824, 1997.
    OpenUrlCrossRefPubMed
    1. Okamoto Y,
    2. Tanaka M,
    3. Fukui T,
    4. Masuzawa T
    : Inhibition of interleukin 17 production by curcumin in mice with collagen-induced arthritis. Biomed Res 22: 299-304, 2011.
    OpenUrl
    1. Wang W,
    2. Zhu R,
    3. Xie Q,
    4. Li A,
    5. Xaio Y,
    6. Li K,
    7. Liu H,
    8. Cui D,
    9. Chen Y,
    10. Wang S
    : Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles. Int J Nanomed 7: 3667-3677, 2012.
    OpenUrl
    1. Kondo A,
    2. Mogi M,
    3. Koshihara Y,
    4. Togani A
    : Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells. Biochem Pharmacol 61: 319-326, 2001.
    OpenUrlCrossRefPubMed
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Curcumin Suppression of Cytokine Release and Cytokine Storm. A Potential Therapy for Patients with Ebola and Other Severe Viral Infections
PETER P. SORDILLO, LAWRENCE HELSON
In Vivo Jan 2015, 29 (1) 1-4;

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Curcumin Suppression of Cytokine Release and Cytokine Storm. A Potential Therapy for Patients with Ebola and Other Severe Viral Infections
PETER P. SORDILLO, LAWRENCE HELSON
In Vivo Jan 2015, 29 (1) 1-4;
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