Research ArticleExperimental Studies

Bone Substitutes Enhance Osteogenic Differentiation of Mesenchymal Stem Cells in Three-dimensional Scaffolds

HENNING HANKEN, JANNA ALPERS, MELANIE BÖBEL, MICHAEL WÖLTJE, PHILIP HARTJEN, REINHARD E. FRIEDRICH, OLE JUNG, CARSTEN RENDENBACH, ALEXANDER GRÖBE, MAX HEILAND, AHMAD AL-DAM, WOLFGANG EICHHORN and RALF SMEETS
In Vivo September 2014, 28 (5) 733-739;

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Figures

  • Figure 1.
    Figure 1.

    Viability and cytotoxicity of mesenchymal stem cells in 3D carriers with poly-L-lactic-acid. A total of 500,000 cells were seeded in fibrin carriers with and without bone substitutes as indicated.

  • Figure 2.
    Figure 2.
    Figure 2.

    A: Alkaline phosphatase activity of mesenchymal stem cells (MSC) in 3D carriers with poly-L-lactic-acid (PLLA). A totaI of 500,000 cells were seeded in fibrin carriers with and without bone substitutes as indicated. B: General patterns of alkaline phosphatase activity of MSCs in 3D carriers with PLLA.

  • Figure 3.
    Figure 3.

    Gene expression analysis of runt-related transcription factor 2 (RUNX2), collagen type I, osteopontin and osteocalcin in mesenchymal stem cells in 3D carriers with poly-L-lactic-acid. Maximum values of a 14-day period are presented. NC: Negative control; PC: positive control.

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Bone Substitutes Enhance Osteogenic Differentiation of Mesenchymal Stem Cells in Three-dimensional Scaffolds
HENNING HANKEN, JANNA ALPERS, MELANIE BÖBEL, MICHAEL WÖLTJE, PHILIP HARTJEN, REINHARD E. FRIEDRICH, OLE JUNG, CARSTEN RENDENBACH, ALEXANDER GRÖBE, MAX HEILAND, AHMAD AL-DAM, WOLFGANG EICHHORN, RALF SMEETS
In Vivo Sep 2014, 28 (5) 733-739;
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