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Review ArticleClinical StudiesR

Vitamin D3 Deficiency Results in Dysfunctions of Immunity with Severe Fatigue and Depression in a Variety of Diseases

ANNA DOROTHEA HÖCK
In Vivo January 2014, 28 (1) 133-145;
ANNA DOROTHEA HÖCK
Office of Internal Medicine, Cologne, Germany
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  • For correspondence: ad.hoeck{at}t-online.de
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Article Information

vol. 28 no. 1 133-145
PMID 
24425848

Published By 
International Institute of Anticancer Research
Print ISSN 
0258-851X
Online ISSN 
1791-7549
History 
  • Received September 9, 2013
  • Revision received November 4, 2013
  • Accepted November 6, 2013
  • Published online January 14, 2014.

Copyright & License 
Copyright © 2014 The Author(s). Published by the International Institute of Anticancer Research.

Author Information

  1. ANNA DOROTHEA HÖCK⇑
  1. Office of Internal Medicine, Cologne, Germany
  1. Correspondence to: Anna Dorothea Höck, MD, Mariawaldstraße 7, 50935 Cologne, Germany. E-mail: ad.hoeck{at}t-online.de
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January-February 2014
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Vitamin D3 Deficiency Results in Dysfunctions of Immunity with Severe Fatigue and Depression in a Variety of Diseases
ANNA DOROTHEA HÖCK
In Vivo Jan 2014, 28 (1) 133-145;

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Vitamin D3 Deficiency Results in Dysfunctions of Immunity with Severe Fatigue and Depression in a Variety of Diseases
ANNA DOROTHEA HÖCK
In Vivo Jan 2014, 28 (1) 133-145;
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  • Article
    • Abstract
    • Sufficient Supply of Vitamin D3 is Important for Proper Human Cell Functions and Stress Response
    • Physical and Functional Epithelial Barriers are Enhanced by 1,25(OH)2D3
    • Influence of 1,25(OH)2D3 on Antimicrobial Peptides (AMiPs)
    • Auto/Xenophagy as an Important Cellular Rheostat and its Relation to 1,25(OH)2D3 and Cathelicidin
    • Endo- and Phagocytosis are Enhanced by 1,25(OH)2D3 and Cathelicidin
    • 1,25(OH)2D3 Induces Immune-tolerant Myeloid Dendritic Cells and Regulatory T-Cells
    • Cathelicidin and NK cells in Innate and Adaptive Immunity
    • Vitamin D Receptor and 1,25(OH)2D3 Are most Important for Invariant NK T-cells
    • Intra-epithelial CD8αα TCRαβ Cells are Invariant NK T-cell-equivalent gut Mucosa Cells and Essential for Local Immune Balance
    • Activated B-cells Express VDR, and B-cell/invariant NK T-cell Interactions Modulate Immune Responses
    • Discussion
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Keywords

  • Vitamin D3 deficiency
  • cathelicidin
  • auto/xenophagy
  • immune imbalance
  • chronic diseases
  • review
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