Proteomic Profiling to Identify Prognostic Biomarkers in Heart Failure

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Figure 1.
Relationship between clinical status and biomarker peak intensity for biomarker peaks at: (A) m/z 11834, (B) m/z 14766, and (C) m/z 5351. Patients are grouped into controls, and for patients with LVEF ≤40%, by NYHA class (III/IV combined). The peak intensity levels are presented as box (25th percentile, median, 75th percentile) and whisker (10th and 90th percentiles) plots. Patient numbers are indicated. The Jonckheere-Terpstra test was used to assess the trend in peak intensity levels across patient groups.
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Figure 2.
Increased expression of peak m/z 11834 in patients with ICDs that died compared to those that survived. A region of mass spectra from 10 to 16 kDa has been expanded and aligned for 4 patients that died during follow-up and 4 patients that survived. Peak intensity for biomarker peak m/z 11834 (arrow) is higher in patients that died versus those that survived. The x-axis is the ratio of mass-to-charge (m/z) and the y-axis represents peak intensity.