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Research ArticleClinical Studies

Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany

CLAUDIA VOLLBRACHT, BERTHOLD SCHNEIDER, VAN LEENDERT, GABRIELE WEISS, LEO AUERBACH and JOSEF BEUTH
In Vivo November 2011, 25 (6) 983-990;
CLAUDIA VOLLBRACHT
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  • For correspondence: hans.beuth@uk-koeln.de claudia.vollbracht@pascoe.de
BERTHOLD SCHNEIDER
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VAN LEENDERT
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GABRIELE WEISS
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LEO AUERBACH
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JOSEF BEUTH
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  • For correspondence: hans.beuth@uk-koeln.de claudia.vollbracht@pascoe.de
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Abstract

Aim: The aim of the study was to evaluate under praxis conditions the safety and efficacy of intravenous (i.v.) vitamin C administration in the first postoperative year of women with breast cancer. Patients and Methods: Epidemiological multicentre cohort study, including 15 gynaecologists and general practitioners representatively distributed in Germany. Data from 125 breast cancer patients in UICC stages IIa to IIIb were selected for the study. A total of 53 of these patients were treated with i.v. vitamin C (supplied as Pascorbin® 7.5 g) additional to standard tumour therapy for at least 4 weeks (study group) and 72 without this additional therapy (control group). Main outcome measures were efficacy in regard to outcome and severity of disease- or therapy-induced complaints during adjuvant chemo- and radiotherapy and aftercare. Results: Comparison of control and study groups revealed that i.v. vitamin C administration resulted in a significant reduction of complaints induced by the disease and chemo-/radiotherapy, in particular of nausea, loss of appetite, fatigue, depression, sleep disorders, dizziness and haemorrhagic diathesis. After adjustment for age and baseline conditions (intensity score before adjuvant therapy, chemotherapy, radiotherapy), the overall intensity score of symptoms during adjuvant therapy and aftercare was nearly twice as high in the control group compared to the study group. No side-effects of the i.v. vitamin C administration were documented. Discussion: Oxidative stress and vitamin C deficiency play an important role in the etiology of adverse effects of guideline-based adjuvant chemo-/radiotherapy. Restoring antioxidative capacity by complementary i.v. vitamin C administration helps to prevent or reduce disease-, or therapy-induced complaints in breast cancer patients. Conclusion: Complementary treatment of breast cancer patients with i.v. vitamin C was shown to be a well tolerated optimization of standard tumour-destructive therapies, reducing quality of life-related side-effects.

  • Ascorbic acid
  • breast neoplasm
  • intravenous vitamin C
  • tumour pain
  • side-effects
  • depression
  • fatigue
  • surgery
  • Received June 21, 2011.
  • Revision received August 5, 2011.
  • Accepted August 9, 2011.
  • Copyright © 2011 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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In Vivo: 25 (6)
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Vol. 25, Issue 6
November-December 2011
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Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany
CLAUDIA VOLLBRACHT, BERTHOLD SCHNEIDER, VAN LEENDERT, GABRIELE WEISS, LEO AUERBACH, JOSEF BEUTH
In Vivo Nov 2011, 25 (6) 983-990;

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Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany
CLAUDIA VOLLBRACHT, BERTHOLD SCHNEIDER, VAN LEENDERT, GABRIELE WEISS, LEO AUERBACH, JOSEF BEUTH
In Vivo Nov 2011, 25 (6) 983-990;
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