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Research ArticleExperimental Studies

Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature

VINCENT C. LOMBARDI, KATHRYN S. HAGEN, KENNETH W. HUNTER, JOHN W. DIAMOND, JULIE SMITH-GAGEN, WEI YANG and JUDY A. MIKOVITS
In Vivo May 2011, 25 (3) 307-314;
VINCENT C. LOMBARDI
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  • For correspondence: vclombardi@wpinstitute.org vclombardi@gmail.com
KATHRYN S. HAGEN
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KENNETH W. HUNTER
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JOHN W. DIAMOND
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JULIE SMITH-GAGEN
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WEI YANG
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JUDY A. MIKOVITS
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Abstract

Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease. Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS. Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm. Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity. Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.

  • XMRV
  • CSF cytokine
  • chemokine
  • Random Forest
  • Received January 20, 2011.
  • Revision received February 25, 2011.
  • Accepted February 28, 2011.
  • Copyright © 2011 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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In Vivo: 25 (3)
In Vivo
Vol. 25, Issue 3
May-June 2011
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Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
VINCENT C. LOMBARDI, KATHRYN S. HAGEN, KENNETH W. HUNTER, JOHN W. DIAMOND, JULIE SMITH-GAGEN, WEI YANG, JUDY A. MIKOVITS
In Vivo May 2011, 25 (3) 307-314;

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Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
VINCENT C. LOMBARDI, KATHRYN S. HAGEN, KENNETH W. HUNTER, JOHN W. DIAMOND, JULIE SMITH-GAGEN, WEI YANG, JUDY A. MIKOVITS
In Vivo May 2011, 25 (3) 307-314;
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