Research ArticleExperimental Studies

Increased In Vivo Efficacy of Lenalidomide by Addition of Piroctone Olamine

YOUNG KIM, PETRA ALPMANN, SABINE BLAUM-FEDER, SIMON KRÄMER, TOMOYUKI ENDO, DESHENG LU, DENNIS CARSON and INGO G.H. SCHMIDT-WOLF
In Vivo January 2011, 25 (1) 99-103;

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Figures

  • Figure 1.
    Figure 1.

    Flow cytometric analysis of PO in human OPM-2 myeloma cells. 1×105 cells were cultured with or without 0.1 μM PO for three days. Cell viability was measured by DIOC6 staining in flow cytometry. A representative experiment is shown.

  • Figure 2.
    Figure 2.

    Flow cytometric analysis of PO in murine MPC11 myeloma cells. 1×105 cells were cultured with various concentrations of PO for three days. Then cell viability was measured by DIOC6 staining in flow cytometry. Results represent data from two separate experiments. Data are shown as means.

  • Figure 3.
    Figure 3.

    In vivo effect of PO in MPC11-bearing mice. PO was administered orally by gavage at a concentration of 450 μg/day/mouse. Tumor growth in mice is presented. Six animals were used in each group. The observation time was 60 days.

  • Figure 4.
    Figure 4.

    In vivo effect of PO in MPC11-bearing mice. PO was administered orally by gavage at a concentration of 450 μg/day/mouse. Overall survival of mice is presented. Six animals were used in each group. The observation time was 60 days.

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Increased In Vivo Efficacy of Lenalidomide by Addition of Piroctone Olamine
YOUNG KIM, PETRA ALPMANN, SABINE BLAUM-FEDER, SIMON KRÄMER, TOMOYUKI ENDO, DESHENG LU, DENNIS CARSON, INGO G.H. SCHMIDT-WOLF
In Vivo Jan 2011, 25 (1) 99-103;
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