Figure 1.
Representative photomicrographs of morphologic changes in rat kidneys. A, B: Control kidney. C, D: Irradiated rat kidneys at 8 weeks, showing glomerular tuft capsular adhesion, thickening of the basement membrane Bowman's capsule in glomeruli (arrowhead) and ballon-like cellular degeneration, cytoplasmic vacuolization and loss of luminal brush border in tubules (arrow). G, H: Mesangial sclerosis (curved arrow), segmental mesangiolysis (asterisk) and tubular atrophy (X) at 24 weeks postirradiation. E, F, J, K: Amifostine-pretreated rat kidneys at the relevant time point, showing marked reduction of glomerular and tubular damage. (A, C, G, E, J; H&E, B, D, H, F, K; PAS) Scale bar: 50 μm.