Research ArticleExperimental Studies

Differential Effect of Phenothiazines on MRP1 and P-Glycoprotein Activity

OLGA WESOŁOWSKA, JOSEPH MOLNAR, IMRE OCSOVSZKI and KRYSTYNA MICHALAK
In Vivo November 2009, 23 (6) 943-947;

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Figures

  • Figure 1.
    Figure 1.

    Rhodamine 123 accumulation in the resistant mouse T lymphoma cell line L5178 MDR not treated by a modulator (A), treated by 10 μg/ml of verapamil (B), treated by 4 μg/ml of thiethylperazine (C), and in the parental sensitive cell line L5178Y (D).

  • Figure 2.
    Figure 2.

    The influence of phenothiazine derivatives (at 4 μg/ml) on rhodamine 123 accumulation by P-glycoprotein-expressing L5178 MDR cell line (mean±S.D. of three independent experiments). MDR control was not treated with modulator.

  • Figure 3.
    Figure 3.

    The influence of thiethylperazine, thiethylperazine plus 25 μM of orthovanadate, and thiethylperazine plus 50 μM of benzbromarone on BCPCF efflux out of human erythrocytes (mean±S.D. of three independent experiments for thiethylperazine alone, see Materials and Methods for other experiments).

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Differential Effect of Phenothiazines on MRP1 and P-Glycoprotein Activity
OLGA WESOŁOWSKA, JOSEPH MOLNAR, IMRE OCSOVSZKI, KRYSTYNA MICHALAK
In Vivo Nov 2009, 23 (6) 943-947;
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