Article Figures & Data
Figures
- Figure 1.
Stages of the multi-step process of rat tongue carcinogenesis. (A) no histopathological change (control), (B) hyperplasia and hyperkeratosis, (C) epithelial dysplasia, (D) squamous cell carcinoma of well-differentiated type. (Hematoxylin and eosin stain; Bar=30 μm).
- Figure 2.
Immunohistochemical staining for p16. (A) rat control epithelium; (B) pre-neoplastic lesion after 12 weeks of carcinogen administration and (C) squamous cell carcinoma of well-differentiated type (Bar=30 μm).
- Figure 3.
P16 labeling index in the negative control (zero) and those exposed to 4-nitroquinoline 1-oxide for 4, 12 or 20 weeks. Values are means±S.D. *p<0.05 when compared to negative control group.
- Figure 4.
Immunohistochemical staining for pRb. (A) rat control epithelium; (B) pre-neoplastic lesion after 12 weeks of carcinogen administration and (C) squamous cell carcinoma of well-differentiated type (Bar=30 μm).
- Figure 5.
Rb labeling index in the negative control (zero) and those exposed to 4-nitroquinoline 1-oxide for 4, 12 or 20 weeks. Values are ±S.D. *p<0.05 when compared to negative control group.
- Figure 6.
Immunohistochemical staining for p21. (A) rat control epithelium, (B) pre-neoplastic lesion after 12 weeks of carcinogen administration and (C) squamous cell carcinoma of well-differentiated type (Bar=30 μm).
- Figure 7.
P21 labeling index in the negative control (zero) and those exposed to 4-nitroquinoline 1-oxide for 4, 12 or 20 weeks. Values are means±S.D. p>0.05, not detected.
