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Research ArticleExperimental Studies

Antiviral Activities of Extracts of Euphorbia hirta L. against HIV-1, HIV-2 and SIVmac251

ÁGNES GYURIS, LÁSZLÓ SZLÁVIK, JÁNOS MINÁROVITS, ANDREA VASAS, JOSEPH MOLNÁR and JUDIT HOHMANN
In Vivo May 2009, 23 (3) 429-432;
ÁGNES GYURIS
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LÁSZLÓ SZLÁVIK
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JÁNOS MINÁROVITS
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ANDREA VASAS
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JOSEPH MOLNÁR
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JUDIT HOHMANN
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  • For correspondence: hohmann@pharm.u-szeged.hu
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Abstract

The antiretroviral activities of extracts of Euphorbia hirta were investigated in vitro on the MT4 human T lymphocyte cell line. The cytotoxicities of the extracts were tested by means of the MTT cell proliferation assay, and then the direct effects of the aqueous extract on HIV-1, HIV-2 and SIVmac251 reverse transcriptase (RT) activity were determined. A dose-dependent inhibition of RT activity was observed for all three viruses. The HIV-1 inhibitory potency of E. hirta was studied further, and the activities of the aqueous and 50% methanolic extracts were compared. The 50% methanolic extract was found to exert a higher antiretroviral effect than that of the aqueous extract. The 50% MeOH extract was subjected to liquid-liquid partition with dichloromethane, ethyl acetate and water. Only the remaining aqueous phase exhibited significant antiviral activity; all the lipophilic extracts appeared to be inactive. After removal of the tannins from the aqueous extract, the viral replication inhibitory effect was markedly decreased, and it was therefore concluded that tannins are most probably responsible for the high antiretroviral activity.

  • Euphorbia hirta
  • Euphorbiaceae
  • antiviral activity
  • HIV-1
  • HIV-2
  • SIVmac251
  • Received December 23, 2008.
  • Revision received March 13, 2009.
  • Accepted March 31, 2009.
  • Copyright © 2009 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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In Vivo: 23 (3)
In Vivo
Vol. 23, Issue 3
May-June 2009
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Antiviral Activities of Extracts of Euphorbia hirta L. against HIV-1, HIV-2 and SIVmac251
ÁGNES GYURIS, LÁSZLÓ SZLÁVIK, JÁNOS MINÁROVITS, ANDREA VASAS, JOSEPH MOLNÁR, JUDIT HOHMANN
In Vivo May 2009, 23 (3) 429-432;

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Antiviral Activities of Extracts of Euphorbia hirta L. against HIV-1, HIV-2 and SIVmac251
ÁGNES GYURIS, LÁSZLÓ SZLÁVIK, JÁNOS MINÁROVITS, ANDREA VASAS, JOSEPH MOLNÁR, JUDIT HOHMANN
In Vivo May 2009, 23 (3) 429-432;
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