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Research ArticleExperimental Studies

Possible Relation Between Histone 3 and Cytokeratin 18 in Human Hepatocellular Carcinoma

CHIN-CHIN HO, CHIUNG-CHI CHENG, YI-HSIANG LIU, REN-JENG PEI, YUNG-HSIANG HSU, KUN-TU YEH, LU-CHANG HO, MING-CHUANG TSAI and YIH-SHYONG LAI
In Vivo July 2008, 22 (4) 457-462;
CHIN-CHIN HO
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CHIUNG-CHI CHENG
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YI-HSIANG LIU
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REN-JENG PEI
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YUNG-HSIANG HSU
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KUN-TU YEH
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LU-CHANG HO
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MING-CHUANG TSAI
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YIH-SHYONG LAI
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  • For correspondence: yslaick18@yahoo.com.tw
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Abstract

Background: Previously we found some low molecular weight proteins identified as histone in hepatocelluar carcinoma. Our objective was to clarify whether the co-immunoprecipitation of histone and cytokeratin 18 was an artifact or not. Materials and Methods: Histone 3 and cytokeratin 18 were investigated in three cases of human hepatocellular carcinoma and one case of normal liver tissue. Nuclei of the tissues were isolated; the proteins inside the nuclei were analyzed by Western blot. Results: The results revealed histone was co-immunoprecipitated with cytokeratin 18 in hepatocellular carcinoma. It was speculated that modulation of the cytoskeleton in human hepatocellular carcinoma might disturb the organization of the nucleoskeleton. The unstable nucleoskeleton might further cause instability and fragility of nuclei, thus possibly exposing the histone and co-immunoprecipitating it with cytokeratin 18. Conclusion: The evidence might indicate that expression of histone 3 was highly related to modulation of cytokeratin 18 and might play an important role in tumorigenesis of hepatocellular carcinoma.

  • Cytokeratin
  • histone
  • modulation
  • hepatocellular carcinoma
  • immunoprecipitation

Footnotes

  • ↵* All three authors contributed equally to this work.

  • Received January 31, 2008.
  • Revision received April 15, 2008.
  • Accepted April 21, 2008.
  • Copyright © 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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In Vivo: 22 (4)
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Vol. 22, Issue 4
July-August 2008
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Possible Relation Between Histone 3 and Cytokeratin 18 in Human Hepatocellular Carcinoma
CHIN-CHIN HO, CHIUNG-CHI CHENG, YI-HSIANG LIU, REN-JENG PEI, YUNG-HSIANG HSU, KUN-TU YEH, LU-CHANG HO, MING-CHUANG TSAI, YIH-SHYONG LAI
In Vivo Jul 2008, 22 (4) 457-462;

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Possible Relation Between Histone 3 and Cytokeratin 18 in Human Hepatocellular Carcinoma
CHIN-CHIN HO, CHIUNG-CHI CHENG, YI-HSIANG LIU, REN-JENG PEI, YUNG-HSIANG HSU, KUN-TU YEH, LU-CHANG HO, MING-CHUANG TSAI, YIH-SHYONG LAI
In Vivo Jul 2008, 22 (4) 457-462;
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