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Research Article

Prevention of Lethal Tumor Growth and Generation of Long-lasting Immunity In Vivo Using CD137L and Interleukin-12 Gene Transfer

YOUNG KIM, JOHN W. STREHL, MARCUS GORSCHLÜTER, CARSTEN ZISKE and INGO G.H. SCHMIDT-WOLF
In Vivo May 2008, 22 (3) 337-343;
YOUNG KIM
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JOHN W. STREHL
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MARCUS GORSCHLÜTER
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CARSTEN ZISKE
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INGO G.H. SCHMIDT-WOLF
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  • For correspondence: Ingo.Schmidt-Wolf@ukb.uni-bonn.de
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Abstract

In a wide range of solid tumors, overexpression of CD137L has been shown to induce tumor immunity partly due to the stimulation of CD8+ CTL, which was even increased when immunotherapy with interleukin-12 (IL12) was additionally employed. However, little in known regarding hematologic neoplasias in this respect. Of the 8 animals receiving IL12-secreting tumor cells, 2 died. Animals treated with CD137L-expressing tumor cells and the combination group, all animals survived. Interestingly, re-challenge with wild-type tumor cells was rejected by all animals in the CD137L group and all remaining animals in the IL12 group, while these in the control group died. IL12- and CD137L-transfected plasmocytoma cells prevented tumor growth and induced long-lasting immunity. Our results warrant follow-up for future clinical use in patients with myeloma.

  • CD137L
  • interleukin-12
  • plasmocytoma
  • gene therapy
  • in vivo

Footnotes

  • ↵* Both authors contributed equally to this work.

  • Received December 14, 2007.
  • Revision received March 6, 2008.
  • Accepted March 7, 2008.
  • Copyright © 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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In Vivo: 22 (3)
In Vivo
Vol. 22, Issue 3
May-June 2008
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Prevention of Lethal Tumor Growth and Generation of Long-lasting Immunity In Vivo Using CD137L and Interleukin-12 Gene Transfer
YOUNG KIM, JOHN W. STREHL, MARCUS GORSCHLÜTER, CARSTEN ZISKE, INGO G.H. SCHMIDT-WOLF
In Vivo May 2008, 22 (3) 337-343;

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Prevention of Lethal Tumor Growth and Generation of Long-lasting Immunity In Vivo Using CD137L and Interleukin-12 Gene Transfer
YOUNG KIM, JOHN W. STREHL, MARCUS GORSCHLÜTER, CARSTEN ZISKE, INGO G.H. SCHMIDT-WOLF
In Vivo May 2008, 22 (3) 337-343;
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