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Research ArticleClinical Studies

Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity, and their Clinical Relevance

MIRA MEEUS, JO NIJS, NEIL MCGREGOR, ROMAIN MEEUSEN, GUY DE SCHUTTER, STEVEN TRUIJEN, MARC FRÉMONT, ELKE VAN HOOF and KENNY DE MEIRLEIR
In Vivo January 2008, 22 (1) 115-121;
MIRA MEEUS
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JO NIJS
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  • For correspondence: Jo.Nijs@vub.ac.be
NEIL MCGREGOR
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ROMAIN MEEUSEN
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GUY DE SCHUTTER
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STEVEN TRUIJEN
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MARC FRÉMONT
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ELKE VAN HOOF
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KENNY DE MEIRLEIR
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Abstract

This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (rs=0.570; p=0.021), protein kinase R (PKR) (rs=0.716; p=0.002) and elastase activity (rs=0.500; p=0.049). RNase L activity was related to elastase (rs=0.547; p=0.028) and PKR activity (rs=0.625; p=0.010). RNase L activity (rs=0.535; p=0.033), elastase activity (rs=0.585; p=0.017) and RNase L cleavage (rs=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.

  • RNase L
  • elastase
  • protein kinase R
  • nitric oxide
  • chronic fatigue syndrome
  • daily functioning

Footnotes

  • Received July 5, 2007.
  • Revision received October 26, 2007.
  • Accepted November 19, 2007.
  • Copyright © 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity, and their Clinical Relevance
MIRA MEEUS, JO NIJS, NEIL MCGREGOR, ROMAIN MEEUSEN, GUY DE SCHUTTER, STEVEN TRUIJEN, MARC FRÉMONT, ELKE VAN HOOF, KENNY DE MEIRLEIR
In Vivo Jan 2008, 22 (1) 115-121;

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Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity, and their Clinical Relevance
MIRA MEEUS, JO NIJS, NEIL MCGREGOR, ROMAIN MEEUSEN, GUY DE SCHUTTER, STEVEN TRUIJEN, MARC FRÉMONT, ELKE VAN HOOF, KENNY DE MEIRLEIR
In Vivo Jan 2008, 22 (1) 115-121;
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