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Research ArticleClinical Studies

Neuropsychological Assessment of Cognitive Function in Chronic Alcohol-dependent Patients and Patients with Alzheimer's Disease

IOANNIS LIAPPAS, IOULIA THEOTOKA, ELISABETH KAPAKI, IOANNIS ILIAS, GEORGE P. PARASKEVAS and CONSTANTINE R. SOLDATOS
In Vivo November 2007, 21 (6) 1115-1118;
IOANNIS LIAPPAS
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IOULIA THEOTOKA
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  • For correspondence: iliatheotoka@yahoo.com
ELISABETH KAPAKI
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IOANNIS ILIAS
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GEORGE P. PARASKEVAS
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CONSTANTINE R. SOLDATOS
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Abstract

Background: Heavy and chronic alcohol dependence and Alzheimer's disease may share some neuropsychological characteristics. Patients and Methods: The pattern of neuropsychological characteristics of 33 alcohol-dependent patients who reported memory disturbances were evaluated and compared to the neuropsychological performance of 38 patients with mild-stage Alzheimer's disease and 73 healthy subjects, serving as controls. Alcohol-dependent patients were examined with tools concerning the pattern of alcohol abuse and problems related to alcohol consumption. All groups completed a full battery of neuropsychological tests for the assessment of cognitive functions, such as different kinds of memory, attention, executive function etc. Results: Alcohol-dependent patients fared worse compared to the control subjects in every test used. The comparison of alcohol-dependent patients versus patients with Alzheimer's disease showed that the latter are much more burdened, as far as cognition is concerned, in all aspects of memory. Conclusion: Alcohol-dependent patients, even if they are not demented, have mild cognitive impairment in all domains of cognition (memory and frontal functions) in comparison with controls which performed within the norms. Verbal fluency, working memory and frontal functions were impaired at the same degree in alcohol-dependent patients and in patients with Alzheimer's disease. Memory problems were more pronounced in Alzheimer's disease patients.

  • Alcohol-dependence
  • Alzheimer's disease
  • neuropsychological assessment
  • cognitive function

Footnotes

  • Received April 3, 2007.
  • Revision received September 5, 2007.
  • Accepted September 17, 2007.
  • Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Vol. 21, Issue 6
November-December 2007
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Neuropsychological Assessment of Cognitive Function in Chronic Alcohol-dependent Patients and Patients with Alzheimer's Disease
IOANNIS LIAPPAS, IOULIA THEOTOKA, ELISABETH KAPAKI, IOANNIS ILIAS, GEORGE P. PARASKEVAS, CONSTANTINE R. SOLDATOS
In Vivo Nov 2007, 21 (6) 1115-1118;

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Neuropsychological Assessment of Cognitive Function in Chronic Alcohol-dependent Patients and Patients with Alzheimer's Disease
IOANNIS LIAPPAS, IOULIA THEOTOKA, ELISABETH KAPAKI, IOANNIS ILIAS, GEORGE P. PARASKEVAS, CONSTANTINE R. SOLDATOS
In Vivo Nov 2007, 21 (6) 1115-1118;
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