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Research ArticleClinical Studies

Intraarterial Hepatic Chemoembolization of Liver Metastases from Colorectal Cancer Adopting Irinotecan-eluting Beads: Results of a Phase II Clinical Study

GIAMMARIA FIORENTINI, CAMILLO ALIBERTI, GINA TURRISI, ALESSANDRO DEL CONTE, SUSANNA ROSSI, GIORGIO BENEA and PETROS GIOVANIS
In Vivo November 2007, 21 (6) 1085-1091;
GIAMMARIA FIORENTINI
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  • For correspondence: oncologiaempoli@usl11.tos.it
CAMILLO ALIBERTI
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GINA TURRISI
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ALESSANDRO DEL CONTE
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SUSANNA ROSSI
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GIORGIO BENEA
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PETROS GIOVANIS
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Abstract

Since November 2005 a clinical trial of intraarterial hepatic chemoembolization (TACE) with irinotecan-eluting beads has been ongoing in 20 patients affected by liver metastases from colorectal cancer in a palliative setting. A high response rate (80%), with reduction of lesional contrast enhancement in all responding patients was found. The procedure was well tolerated by most patients, with a median duration of hospitalization of 3 days (range 1-10 days). The most important adverse event was abdominal pain during the injection. Adequate supportive treatment with antibiotic and antiemetic prophylaxis, dexamethasone, and intravenous hydration is strictly necessary until the serum levels of transaminases are stabilized and in order to prevent infections. Major analgesics such as morphine must be used before and after the procedure. Our results suggest that TACE using irinotecan-eluting beads is feasible and active in pretreated patients with liver metastases from CRC.

  • Liver metastasis
  • colorectal cancer
  • DC beads
  • intraarterial chemotherapy
  • hepatic angiography
  • irinotecan

Footnotes

    • Received June 29, 2007.
    • Revision received September 5, 2007.
    • Accepted October 1, 2007.
    • Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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    In Vivo: 21 (6)
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    Intraarterial Hepatic Chemoembolization of Liver Metastases from Colorectal Cancer Adopting Irinotecan-eluting Beads: Results of a Phase II Clinical Study
    GIAMMARIA FIORENTINI, CAMILLO ALIBERTI, GINA TURRISI, ALESSANDRO DEL CONTE, SUSANNA ROSSI, GIORGIO BENEA, PETROS GIOVANIS
    In Vivo Nov 2007, 21 (6) 1085-1091;

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    Intraarterial Hepatic Chemoembolization of Liver Metastases from Colorectal Cancer Adopting Irinotecan-eluting Beads: Results of a Phase II Clinical Study
    GIAMMARIA FIORENTINI, CAMILLO ALIBERTI, GINA TURRISI, ALESSANDRO DEL CONTE, SUSANNA ROSSI, GIORGIO BENEA, PETROS GIOVANIS
    In Vivo Nov 2007, 21 (6) 1085-1091;
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